@Article{, title={Establishing the Superiority of Topical Diltiazem Over Compound Cream in the Treatment of Chronic Anal Fissure: A Prospective Analytical Study}, author={Ahmed Nasser Hussein, Maytham Hatam Shahid, Abd Alkhaliq S Abdullah}, journal={Iraqi Postgraduate Medical Journal المجلة العراقية للاختصاصات الطبية}, volume={16}, number={4}, pages={434-437}, year={2017}, abstract={ABSTRACT:BACKGROUND:Anal fissure is an elliptical ulcer in the anal canal extending from the dentate line to the anal verge; chronic anal fissure is a common problem across the world treated largely by surgical methods. The treatment for chronic anal fissure (CAF) has undergone a transformation in recent years from surgical to medical as the common goal is reducing the internal anal sphincter spasm.OBJECTIVE:To assess the efficacy of topical treatment with 2% diltiazem gel (DTZ) in patient with chronic anal fissure versus combination cream.MATERIAL AND METHODS:Consecutive 400 adult male patients with symptomatic chronic anal fissure attending the surgery clinic were enrolled in the study form February 2014- July 2016, 200 patients were treated with topical application of 2% DTZ cream, other 200 patients were treated with combination cream. Patients were followed up for 6 month at regular intervals for symptomatic relief and healing of fissure.RESULT &CONCLUSION:In our study diltiazem 2% gel was more effective than combination cream in the treatment of chronic anal fissure..

} }