TY - JOUR ID - TI - Correlation of Bilirubin and Alkaline Phosphatase in Infantile Patients with Cholestasis AU - Mostafa M. Al‑Bassam, Hassan H. Al‑Saeed1, Hala Sameh Arif2 PY - 2019 VL - 16 IS - 1 SP - 47 EP - 50 JO - Medical Journal of Babylon مجلة بابل الطبية SN - 1812156X 23126760 AB - Background: Early and successful individualized management of infantile cholestasis depends on the time of diagnosis. Objective: Theobjective of the study is to assess the clinical value of serum total bilirubin, direct bilirubin, and alkaline phosphatase in children with cholestasis.Materials and Methods: Sixty patients with diseases and 25 healthy controls distributed into three groups – total/direct bilirubin, and alkalinephosphatase were measured for all case and control studies by enzyme‑linked immunosorbent assay. Results: The results showed serum total,direct bilirubin, and alkaline phosphatase have a highly significantly elevated in intra‑ and extra‑hepatic cholestasis groups when comparedwith control (P < 0.001). There was a significantly elevated serum total and direct bilirubin when compared the extrahepatic cholestatic groupwith intrahepatic cholestatic group (P = 0.002 and 0.017), and there was no statistical difference between the intrahepatic cholestatic patientsand extrahepatic cholestatic group when serum alkaline phosphatase measured (P = 0.610). Conclusion: From these findings, it was concludedthat the level of direct bilirubin in sera of extrahepatic cholestasis group when compared with intrahepatic cholestasis group is elevated, serumtotal bilirubin, and alkaline phosphatase levels are good markers in determining the poor prognosis of cholestasis disease.

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