TY - JOUR ID - TI - Role of 1α-Hydroxylase Enzyme and 25(OH)D as a Biomarker of Vitamin D Metabolism in Chronic Kidney Disease دور انزيم ١ الفا هايدروكسيلز وفيتامين25(OH)D كمؤشر حيوي لايض فيتامين25(OH)D في مرضى الكلى المزمن AU - Hanaa N. Abdullah هناء ناجي عبدالله AU - Ameerah Hameed Mnazzal اميرة حميد منزل PY - 2019 VL - 1 IS - 2 SP - 164 EP - 174 JO - Al-Nisour Journal for Medical Sciences مجلة النسور للعلوم الطبية SN - 26640562 26640554 AB - Chronic kidney disease is identified as a risk factor for vitamin D deficiency, vitamin D deficiency is common and high in the chronic kidney disease population so it is recognized as a significant public health problem. The objective of this study was to 1) measured 25(OH)D and 1α-hydroxylase levels. 2) Correlation between 25(OH)D and 1α-hydroxylase among patients with vitamin D deficient and CKD. Blood samples were collected, from 50 patients suffer from CKD and have Vitamin D deficiency, and 50 healthy persons as control group. The biochemical results showed that blood urea, creatinine, phosphorus and parathyroid hormone levels a highly significant increase in the level of patients compared with controls. The biochemical results showed that blood urea, creatinine, phosphorus and parathyroid hormone levels were highly significant increase in the patients compared with controls. While the results revealed a highly significant reduction (P < 0.01) in 25(OH)D level, calcium and 1α-hydroxylase enzyme among CKD patients when compared with the healthy controls. The biochemical markers showed a highly significantly correlation between serum 25(OH)D and Creatinine, phosphorus and parathyroid hormone (P<0.01). While a highly significant reduction correlation was observed between serum 25(OH)D and calcium, serum 1α-hydroxylase enzyme levels in CKD patients.

تم تحديد مرض الكلى المزمن كعامل خطر لنقص فيتامين25(OH)D ، ويعد نقص فيتامين 25(OH)D شائع في مرضى أمراض الكلى المزمنة و يمثل مشكلة صحية عامة كبيرة. تهدف هذه الدراسة 1) قياس مستويات فيتامين25(OH)D و 1الفا هيدروكسيلاز. 2) العلاقة بين فيتامين25(OH)D و 1الفا هيدروكسيليز بين المرضى الذين يعانون من نقص فيتامين25(OH)D ومرضى الكلى المزمن. تم جمع عينات الدم ، من 50 مريضا يعانون من مرضى الكلى المزم مع نقص فيتامين25(OH)D و 50 من الأشخاص الأصحاء كمجموعة سيطرة. أظهرت النتائج زيادة 0.01)