TY - JOUR ID - TI - Antifungal Activity of Some Plant Extracts AU - Amal Abdul Latif AU - Taisir Khaleel Ismael PY - 2019 VL - 6 IS - 2 SP - 13 EP - 24 JO - Journal of Oral and Dental Research مجلة طب الفم والاسنان SN - 23106417 AB - Background Due to the increase in the microorganism resistance to most of conventional antifungal drug, studies have encouraged to discover novel treatments for infections caused by Candida species. Hence, alternative therapies are crucial and the use of herbal medicines seems being a promising solution for the candidiasis treatment. Materials and Methods the antifungal effect of some medicinal plant extracts (peppermint and pomegranate) was confirmed by some studies. But there was still a lack of knowledge associated with the specificity of these extracts on sensitivity and viability counts of candida albicans, so for this reason this study was conducted. Water extract (peppermint and pomegranate) was prepared, different concentration (5, 10, 15, 20, and 25mg/ml) from them were taken, tested candida albicans was used to evaluate these extracts on its sensitivity, viability counts, and minimum inhibitory concentration (MIC) (in vitro). Results showed that all concentration of pomegranate showed zone of inhibition, there were highly significant differences between concentrations except between (10, 15) and (20, 25), but peppermint revealed zero zone of inhibition on Sabouraud dextrose agar medium. All concentrations of both extracts were effect in reducing viability counts of candida albicans with highly significant differences with Negative control (Distilled water) P<0.05, but there were no significant difference P >0.05with positive control (Nystatin) and with each other. Conclusions All plant extracts used in this study had antifungal effect and influence on candida albicans. For this reason can be used as disinfectants, mouth wash or soaking solutions and as an alternate to drug in the treatment of denture stomatitis.

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