TY - JOUR ID - TI - Evaluation the relation of TNF-alpha in aborted women who suffer from bacterial vaginitis AU - Nadya I. Salih AU - Maisaloon F. Hassan PY - 2018 VL - 24 IS - 2 SP - 95 EP - 103 JO - The Medical Journal of Tikrit University المجلة الطبية لجامعة تكريت SN - 18131638 AB - ABSTRACT: Background The role of infectious diseases in recurrent miscarriage is not clarified yet, but proposed an incidence of 0.5–5%. There are some candidate infectious diseases such as Listeria monocytogenes, Toxoplasma gondii, rubella, herpes simplex virus (HSV), measles, cytomegalovirus, and coxsackie viruses. Aim: This study was aimed at evaluation of the relation of TNF-α level in aborted women infected with bacterial vaginitis. Material and Method A cross sectional study was carried out in Kirkuk city from the beginning of February 2018 to the end of May 2018, deep vaginal swab was collected from 100 women with recurrent abortion and 50 pregnant women (as control group) that belonged to different geographical areas in Kirkuk city and admitted to Kirkuk General Hospital. The swabs samples were cultured on blood agar and MacConkey agar for 24 hour and secondary cultures were done for resulted culture for isolate specific bacteria. Five ml of blood was collected from each women enrolled in this study for TNF-α test using ELISA technique. Results The study showed that 57% of women with recurrent abortion have positive high vaginal swab (HVS) culture comparing with 48% of pregnant women (control group). The current study showed that 86% of women had aborted in the 1st trimester of pregnancy and the least rate of abortion was in the 3rd trimester. The study showed that 52.25% of aborted women were belonged to the age group 27-36 years and highest rate of isolated bacteria from the HVS culture of aborted women was S. aureus (45.61%) while Proteus spp. was not isolated from aborted women. The study found that the highest mean of TNF-α level was denoted among women with abortion comparing with the control group (26.79±9.4 v.s 9.236±0.6 pg/ml) with highly significant relation of TNF-α level with abortion. The study showed that the highest TNF-α mean levels was recorded among women who aborted in the 1st trimester (28.75±8.76 pg/ml) and the lowest mean was noted among the 3rd trimester aborted women with highly significant relation among the groups. Conclusions It was concluded that the there was a highly significant relation of TNF-α level with abortion specially with women suffered from bacterial vaginosis.

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