TY - JOUR ID - TI - Evaluation of the immune response toward Neisseria meningitidis in displaced people receiving A.C.W.Y-meningococcal vaccine AU - Nadya I. Salih AU - Thekra A. Hamada AU - Eapak Q. Hasan PY - 2019 VL - 25 IS - 1 SP - 44 EP - 53 JO - The Medical Journal of Tikrit University المجلة الطبية لجامعة تكريت SN - 18131638 AB - ABSTRACT: Background Meningococcal vaccine refers to any of the vaccines are used to prevent infection by Neisseria meningitidis. Patients & Methods: The present study was carried out from 15th of January 2018 to 15th of June 2018. The number of previously vaccinated for N. meningitidis individuals under study was 68 displaced individuals whose ages were between 5-60 years old. These individuals were living in Laylan refugee camps. The control group who were matched to the patients studied, included 22 blood donors. The blood was collected from each individual enrolled in this study for estimation of anti-meningococcal group ACWY antibodies (IgG, IgM and IgA) level by ELISA technique. The Results: The study showed that the mean of anti-meningococcal IgA-Abs in previously vaccinated persons (0.116 pg/ml), which was higher than that of the control group (0.014 pg/ml), the highest mean of anti-meningococcal IgM-Abs was occurred in previously vaccinated persons (0.2962 IU/ml) comparing with the control group (0.0064 IU/ml) and the highest rate of IgG positive result was (5.88%) present in previously vaccinated persons comparing with the control. The study showed that there was no significant relation of anti-meningococcal antibodies with sex and the highest mean level of anti-meningococcal IgM was recorded among males. This study showed that there was no significant relation of anti-meningococcal antibodies with age and the highest mean level of anti-meningococcal IgA was recorded among the age group 5-16 years. The study showed that the highest mean level of anti-meningococcal IgA, IgM and IgG antibodies were observed among the group of 1-2 months after vaccination (0.1341, 0.3089 and 0.0483 pg/ml respectively).

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