TY - JOUR ID - TI - Effect of Saline Flush and Hand Elevation on the Onset, Time and Duration of the Action of Rocuronium AU - PY - 2020 VL - 19 IS - 3 SP - 199 EP - 204 JO - Iraqi Postgraduate Medical Journal المجلة العراقية للاختصاصات الطبية SN - 83601608 98932708 AB - BACKGROUND:Nondepolarizing neuromuscular blocking drugs (NMBDs) were developed as alternatives to Succinylcholine dueto its serious side effects. Rocuronium bromide has been suggested as the drug of choice when Succinylcholine iscontraindicated. Shortening the onset time of NMBDs is important in some situations, which can be achieved byseveral techniques as the priming principle.OBJECTIVE:To evaluate the effect of fluid (normal saline) flush after Rocuronium bolus on the onset andduration of action.PATIENTS AND METHODS:Sixty patients were divided randomly into two groups; each group had 30 patients: group (A) and group (B). Allof them have undergone surgical operations under general anesthesia. Rocuronium without normal saline wasreceived in induction by 30 patients (Group A), while Rocuronium followed by 20 ml normal saline flush andhand elevation were received in induction by the other 30 patients (Group B). A peripheral nerve stimulator wasused to measure a train-of-four (TOF) stimulation. The time from the disappearance of T1 until the appearance ofT3 is the duration of the action of Rocuronium.RESULTS:In this study, means of time of onset were significantly higher in Group A than that in Group B(61.12 versus 44.41 sec, P= 0.001), and duration of action was higher in Group B than that in GroupA but statistically not significant (40.87 versus 34.61 mints, P= 0.063).CONCLUSION:A 20 ml saline flush and hand elevation immediately after administering a Rocuronium bolus of (0.6 mg/kg)decreased the onset time but did not significantly increase the recovery phase of Rocuronium. Therefore, werecommend to use 20 ml Normal Saline flush and hand elevation after Rocuronium injection as a safe method toget rapid onset for intubation especially when Suxamethonium is contraindicated

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