TY - JOUR ID - TI - Seroprevalence of Toxoplasmosis in patients with chronic liver disease in Baghdad AU - Raghad Hasan Nafal1 AU - Harith Saeed Al-Warid1* AU - Hayder Jamal Al-Sultan2 PY - 2019 VL - 60 IS - 8 SP - 1667 EP - 1672 JO - Iraqi Journal of Science المجلة العراقية للعلوم SN - 00672904 23121637 AB - The influence of Toxoplasma gondii in the pathogenesis of hepatic disease haslately had considerable attention. The objective of this study is to assess theseroprevalence of T. gondii infection in patients with chronic liver disease fromBaghdad-Iraq. All patients have attended Gastroenterology and HepatologyTeaching Hospital, Medical city in Baghdad, Iraq An analytical case–control studywas achieved from September to November 2018. Seventy male patients withchronic liver disease (CLD) and 07 control males (free of chronic liver diseases)participated in this study, their ages were between (18-80) years old. Serum sampleswere taken from all subjects and were analysed with enzyme-linked immunosorbentassay (ELISA) for the presence of anti-T.gondii IgG and IgM antibodies. Theprevalence of anti-T.gondii IgG was significantly higher 62.85% in CLD patientscompared with 27.28% in the control subjects. Anti-T. gondii IgM antibodies werealso showed to be significantly higher in CLD patients compared with controlsubjects. A significant relation between age and the prevalence of T.gondii wasreported in this study. Toxoplasmosis was largely reported among those aged (˃40)years old for both CLD patients and control subjects, while the other age groupsshowed less seroprevalence rates.Sera samples for both CLD patients and control subjects were tested for differentliver enzyme: aspartate aminotransferase (AST), alanine aminotransferase (ALT),and alkaline phosphatase (ALP). ALT was greater in CLD-Toxoplasma positivepatients comparing to CLD-Toxoplasma negative patients. In addition to AST washigher in control-Toxoplasma positive subjects comparing to control-Toxoplasmanegative subjects.These findings show that Toxoplasmosis is high expected to be diagnosed withchronic liver disease patients. Consequently, attention would be focused on healtheducation of peoples at high risk of toxoplasmosis.

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