TY - JOUR ID - TI - Evaluation the correlation between IL-17 level and autoimmune antibodies in hypo and hyper thyroidisms Iraqi patients AU - Marwah F.Fadhil AU - Abdul Al-Kareem A. Al-Kazaz AU - Shaima R.Ibraheem PY - 2019 VL - 60 IS - 9 SP - 1967 EP - 1976 JO - Iraqi Journal of Science المجلة العراقية للعلوم SN - 00672904 23121637 AB - The current study included measuring the level of IL-17A and IL-17F and someautoimmune antibodies related to the thyroid gland in case of hypo andhyperthyroid in Iraqi patients to evaluate the correlation between all the measuredparameters in this study.The study has been carried out in AL-Kindey EndocrineGland and Diabetic Center in Baghdad during the period between February 2018and May 2018, included: 88 patients were divided into three groups, The first groupcomposed of 30 patients of Hypothyroidism that included (26) of them werefemales, (4) of them males. The second group composed of 30 of patients ofHyperthyroidism that included (20) of them were females, (10) of them were males. and second groups were conducted with hypo and hyperthyroidismrespectively.While the third group composed of 28 of healthy individuals (Control)that composed of (25) of them were females, (3) of them were males wasrepresented as control .The results revealed a significant (P < 0.05) correlationbetween TSH concentration and age in patients groups. When the age is more than40 years, the concentration of TSH was noticed to be higher than that in patientsaged less than 40 years. The results show that the level of antibodies wassignificantly increased (P<0.01) in hypo and hyperthyroid patients in comparisonwith the control group. At the same time the level of Anti-TG antibodies was highersignificantly in the hypothyroid patients than its level in hyperthyroid patients group.No significant differences have been found between hypo and hyperthyroid patientsin the level of Anti-TPO and Anti TSH-R antibodies. But its noticed that the higherlevel of Anti-TPO Ab. was found in the hypothyroid group where as higher level ofAnti TSH-R Ab. was found in the hyperthyroid group and simultaneously both typeswere significantly higher than their levels in the control group As well as the resultsdemonstrated a highly significant increase (P< 0.01) in the levels of IL-17 Types (Aand F) in hypo and hyperthyroid patients with bias toward the comparison with thecontrol group. The statistical study showed a significant negative correlationbetween the level of TSH and Anti-TG levels (r= -0.33). While a significant positivecorrelation between the level of Anti-TG and level of IL-17F (r= 0.39) inhypothyroid patients. Also in hypothyroid patients, there is a significant positivecorrelation between the level of Anti-TPO and IL-17A (r= 0.33). In conclusion: Thepositive correlation between IL-17F and Anti-TG and between IL-17A and Anti-TPO in hypothyroid patients refer to increase in the concentration of IL-17 may leadto increase the thyroid autoantibodies, which affect thyroid tissue potency,decreasing thyroid hormone production, according to feedback inhibition loop.

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