TY - JOUR ID - TI - Assessment of Gastric Glandular Atrophy, Intestinal Metaplasia, and Dysplasia among Patients Underwent Upper GIT endoscopy in Karbala AU - Rasha A Neama PY - 2020 VL - 13 IS - 2 SP - 2346 EP - 2354 JO - Karbala Journal of Medicine مجلة كربلاء الطبية SN - 19905483 29580889 AB - Background: The current study is reflecting the commonness of gastric precancerous lesions in patients underwent upper GIT endoscopy. Aim of the study to assess the prevalence of H. pylori related precancerous changes in gastric biopsies and theie clincopathological correlations. Methods: The data was gathered from patients attending Al Hussein teaching hospital and private laboratories. It includes (414) patients who were subjected to esoph-agogastroduodenoscopy in this period. From all patients endoscopic mucosal biopsies were obtained and stained with hematoxylin-eosin. Giemsa stain was used to detect H. pylori organisms. Results: All patients have gastritis and H. Pylori infection was detected in 301 (72.7%) patients. glandular atrophy, intestinal metaplasia and dysplastic changes were detected in 95 (22.9%), 36 (8.7%) and 6 (1.4%) patients respectively. There was a sig-nificant statistical relation between each of glandular atrophy and gastric intestinal metaplasia with age. There was a significant statistical relation between glandular at-rophy and H. Pylori. A significant negative relation between H. Pylori infection and the presence of intestinal metaplasia was observed meanwhile there was a significant correlation between the intestinal metaplasia and dysplastic changes. Conclusion: The current study spots a light on how common the gastric changes can be detected in patients with chronic gastritis. There was a significant relation between the age and gastric glandular atrophy and intestinal metaplasia, a negative significant relation between H.Pylori infection and intestinal metaplastic changes. There was a significant relation between intestinal metaplasia and gastric dysplasia.

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