TY - JOUR ID - TI - Biomedical Applications of Chasmanthera dependens stem extract mediated silver nanoparticles as Antimicrobial, Antioxidant, Anticoagulant, thrombolytic, and Larvicidal agents AU - Daniel Ayandiran Aina PY - 2019 VL - 5 IS - 2 SP - 71 EP - 80 JO - Karbala International Journal of Modern Science مجلة كربلاء العالمية للعلوم الحديثة SN - 2405609X 24056103 AB - The stem extract of Chasmanthera dependenswas used in the biofabrication of silver nanoparticles (AgNPs) in this study. The AgNPs was characterised using UV-visible spectroscopy, Field Emission Scanning Electron Microscope (FESEM), EDX, and the Fourier Transform Infrared Spectroscopy (FTIR). Antibacterial, antioxidant, anticoagulant, thrombolytic and larvicidal activities of the biosynthesised nanoparticles were carried out. There was a peak at 418 nm with a strong silver peak observed around 2.7KeV when the EDX analysis was carried out. The FESEM showed a large number of cubically shaped nanoparticles with sizes ranging from 24.53 to 92.38 nm. CDE-AgNPs was effective against Klebsiella pneumoniaeat 80 μg/ml and 100 μg/ml concentrations while little or no inhibition observed with other bacterial isolates used. CDE-AgNPs displayed potent activity with LC50and LC90of 7.15 μg/ml and 20.86 μg/ml respectively against the Aedes aegyptimosquito larva after 1hr of exposure. The synthesised nanoparticles displayed scavenging activity of DPPH at all concentrations. High anticoagulant efficacy was displayed, while 45.61% clot lysis was observed. This study therefore demonstrated the effectiveness of biosynthesised Chasmanthera dependensstem extract silver nanoparticles as antimicrobial, antioxidant, anticoagulant, thrombolytic and larvicidal agents.

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