@Article{, title={Spectrophotometric determination of alogliptin in bulk and tabletdosage form using bromateebromide mixture as brominating agent}, author={A.V.V.N.K. Sunil Kumara, T.V. Reddyb, C.B. Sekharan}, journal={Karbala International Journal of Modern Science مجلة كربلاء العالمية للعلوم الحديثة}, volume={3}, number={1}, pages={8-17}, year={2017}, abstract={Two simple and sensitive visible spectrophotometric methods (A and B) have been developed and validated for the determi-nation of alogliptin in bulk and tablet dosage forms. The methods are based on the bromination of alogliptin using bromineproduced by the action of HCl on the bromateebromide mixture. The residual bromine is determined with a fixed amount of eithermethyl orange and measuring the absorbance at 505 nm (method A) or methylene blue and measuring the absorbance at 720 nm(method B). Linearity, accuracy and precision were found to be acceptable over the concentration ranges of 1e10mgmL1and2.5e12.5mgmL1for method A and method B, respectively. The detection limits were 0.115mgmL1and 0.210mgmL1formethod A and method B, respectively. The accuracy of the proposed methods was assessed by recovery studies and the percentrecoveries of aloglitpin were found to be 99.91±0.126%e99.99±0.168% for method A and 99.86±0.170%e99.98±0.193% formethod B. The methods were successfully applied to the determination of alogliptin in tablets with percentage recovery of99.84±0.139%e100.20±0.625% (method A) and 99.96±0.351%e10.320±0.422% (method B). The optimized methods werefully validated and proved to be specific, robust, precise and accurate for the quality control of the alogliptin in their pharmaceuticalformulations.

} }