TY - JOUR ID - TI - Comparison Study of Remifentanil and Lidocaine Effect on Hemodynamic Stability during Endotracheal Intubation in Karbala, Iraq. AU - Dhiaa H. Jawad Al-khayat AU - Sawsan M. Jabbar Al-Hasnawi PY - 2021 VL - 14 IS - 1 SP - 2427 EP - 2431 JO - Karbala Journal of Medicine مجلة كربلاء الطبية SN - 19905483 29580889 AB - Background: One of the important tasks of anesthetists is controlling the hemodynamic re-sponses (the increase in blood pressure and heart rate) associated with direct laryngoscopy and endotracheal intubation. Many medications were tried for this purpose; among them were remifentanil and lidocaine are given intravenously after induction of general anesthesia. Objectives: To compare the effect of remifentanil and lidocaine, determine which has a supe-rior activity, on hemodynamic stability, during endotracheal intubation. Patients and methods: This is a randomized controlled clinical trial study conducted on 60 clinically fit patients, planned for elective surgery under general anesthesia with endotracheal intubation. Patients were divided randomly into two groups according to the administration of the Remifentanil or Lidocaine drug. Baseline readings of systolic, diastolic blood pressure, and heart rate were recorded as time 1. General anesthesia was induced using intravenous propofol and rocuronium. The study drug was given, and the readings again were recorded after 90 seconds as time 2, followed by direct laryngoscopy and endotracheal intubation. The third and fourth readings (time 3 & 4) were recorded at one & three minutes postintubation, respectively. Results: Mean systolic blood pressure and heart rate were significantly reduced at times 2 & 3, while mean diastolic blood pressure was significantly reduced at time 2 in the remifentanil group compared to the lidocaine group. Conclusion: Remifentanil is more effective than lidocaine in attenuating the sympathoadrenal response of direct laryngoscopy and endotracheal intubation.

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