@Article{, title={Differential Study of Antimicrobial Activity of Vancomycin andTeicoplanin (Targocid) against Strains of Staphylococcus aureus^ndStreptococci sp. دراسة تفريقية لفعالية المضادات الحيوية للفانكومايسين والتاركوسيد ضد سلالات من المكورات الذهبية العنقودية والمكورات السبحية}, author={Waseem Ali Hasan وسيم علي حسن}, journal={Tikrit Journal of Pharmaceutical Sciences مجلة تكريت للعلوم الصيدلانية}, volume={5}, number={2}, pages={203-207}, year={2009}, abstract={The glycopeptide antibiotics vancomycin and teicoplanin (targocid) are widely used in the treatment of
infections caused by gram positive bacteria. Vancomyc inhibits both transglycosylation and
transpeptidation reaction during peptidoglycan assembly, targocid inhibits peptidoglycan polymerization,
resulting in inhibition of bacterial cell wall synthesis and cell death. In this study twenty strains of
streptococcus pyogenes and streptococcus pneumoniae and twenty five strains of staphylococcus a?lreus
were collected from different infections. MICs and MBCs of vancomycin and targocid were determined
against the bacterial strains, the MICs of vancomycin for the streptococcus strains were 4-8 pg /ml
compared with 8-16 pg/ml for targocid and MICs of targocid for staphylococcus aureus were 4-16 ltglml
MBC for the same strains were 8-32 pg/ml. the conclusion of this study was that targocid was less active
than vancomycin against staphylococci but equal or more active against streptococci specifically it
presents excellent in vitro activity against streptococcus pneumonio strains.

} }