@Article{, title={Preparation of2 - thio ether - 1, 3, 4- oxadiuzole derivatives used asantibacterial and antifungus agents تحضير بعض مشتقات مركبات 2-ثايو ايثر - 1,3,4- اوكساديازول والتي تستخدم كمضادات بكتيرية وفطرية}, author={Abed-M-Daher Al-joubory عبد محمد ظاهر and Ayad -S- Hamad اياد سليمان حمد}, journal={Tikrit Journal of Pharmaceutical Sciences مجلة تكريت للعلوم الصيدلانية}, volume={6}, number={2}, pages={169-179}, year={2010}, abstract={lsonicotinic acid, o-hydroxy benzoic acid, p-chlorobenzoic acid, p-nitro benmicacid and
o-acetyl be1120ic acid, have been csterificated wilh absolute ethanol using Fisher method
to prepare compov11ds [1 -~). TileS<: compounds were converted to acid hydro2idcs [6-101
by the reaction with hydrazinc hydrate. Tile acid hydrazides were ~llowed to react with
cmbon disulfide (CS2) in th~ presence of potassium hydroxide and ethanol to produce 2-
substitutetl I, 3, 4- oxndiazolc -5-thiol [11 - 15). Thio ether derivatives as two groups (16-
20) and (21·25) respectively huve been prepared by the reaction between compounds fl l-
15) and alk')'l or aryl halide, {p-bromo benzyl bromide anrl 2,4- dinitrochlorobenzene)
respectively. The prepared compounds wac identified by FT.l.R , melting point and H'NlviR
was used to support tbe structure of tllc compounds 2·(4-cl>lorophenyl)-5-(2,4-
dinltrophcoyl thio )·1,3 ,4 -oKaoxadiazolc which c;m be used as anti bacterial and anti fungus agents.

} }