TY - JOUR ID - TI - Application of Nano-Particulate Drug Delivery Systems to Deliver Therapeutic Agents into Cancer Cells AU - Qasim Chyad Abdulzah-ra AU - Rana Majeed Hameed AU - Narjes Alfuraiji AU - Weam A Kadhim PY - 2021 VL - 14 IS - 2 SP - 2496 EP - 2512 JO - Karbala Journal of Medicine مجلة كربلاء الطبية SN - 19905483 29580889 AB - Cancer is a disorder where a group of cells grows uncontrollably, ignoring the physiological rules of cells division. Since its discovery (although the word cancer was not used)3000 BC, extraordinary research aims to uncover novel therapeutic strategies for combating it. Current-ly, over 60% of clinical trials over the globe focus on cancer. The type of cancer, site, and stage of progression are among the factors determining the treatment selection. Traditional treatment approaches include chemotherapy, surgery, radiation, and radiation-based surgical knives. Side effects associated with traditional therapy highlights the need for novel cancer treatment. Nanotechnology is widely investigated and utilized to treat cancer, where nanoparticles have had a vital role in delivering anticancer medication. Nanoparticle-based drug delivery pro-vides several advantages over conventional drug delivery, including enhanced biocompatibil-ity, stability, permeability, and retention effect, as well as precision targeting. It has also been proven to tackle the resistance to anticancer drugs by targeting the underlying mechanism (drug efflux transporters overexpression, imperfect apoptotic pathways, and a hypoxic envi-ronment), enhancing multidrug resistance reversal. Moreover, nanoparticles' role in immuno-therapy is undergoing investigation due to their essential role in treating cancer. The current article highlights the role of NP in delivering a chemotherapeutic medication, targeted treat-ment, and the mechanisms of targeting.

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