@Article{, title={Prognostic values of β2 microglobulin, interleukin‑4, and interleukin‑6 in patients with different stages of chronic lymphocytic leukemia}, author={Dr. Yaseen M. Taher}, journal={Iraq Joural of Hematology المجلة العراقية لامراض الدم}, volume={9}, number={1}, pages={47-50}, year={2020}, abstract={BACKGROUND: Chronic lymphocytic leukemia (CLL) is a monoclonal disorder characterized byrelentless accumulation of monoclonal B‑cell. Beta‑2 microglobulin (β2m) is an extracellular proteinthat is bound to the chain of Class 1 major histocompatibility complex molecule, which is presenton all nucleated cells. Interleukin‑4 (IL‑4) is a T‑cell‑derived pleiotropic cytokine which is involvedin the mechanism of survival of leukemic B‑cell. IL‑6 is a pleiotropic cytokine produced in the siteof inflammation; it plays a major role in the acute‑phase response. β2m, IL‑4, and IL‑6 may haveprognostic value in patients with CLL.OBJECTIVES: The aims of this study were to estimate the levels of β2m, IL‑4, and IL‑6 in differentstages in patients with CLL and to know if there is prognostic significance of β2m, IL‑4, and IL‑6 inthose patients.PATIENTS AND METHODS: This study was conducted on fifty patients from March 2013 to March2015 including 36 males and 14 females; all were newly diagnosed CLL. Those patients weredivided into two groups depending on the stages of disease: Group I (21) patients and Group II (29)patients according to the Rai staging system. Diagnosis of CLL was determined for all those patientsby complete blood count and blood films and flow cytometry. The estimation of β2m, IL‑4, and IL‑6was done by enzyme‑linked immunosorbent assay technique.RESULTS: The male‑to‑female ratio was 2.3:1; there were 29 (58%) patients in Group I (Rai Stages0, I, and II) and 21 patients (42%) in Group II (Rai Stages III and IV). β2m, IL‑4, and IL‑6 were elevatedin patients with advance stage of the disease as the levels of these prognostic markers was higherin Group II compared to Group I.CONCLUSION: The elevation of β2‑m, IL‑4, and IL‑6 indicates bad prognosis of the disease andpoor outcome because the serum level of β2m, IL‑4, and IL‑6 is increased in the advanced stagesof the disease.

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