TY - JOUR ID - TI - A Possible Mechanism of The Hepatotoxic Action of Dihydromethysticin Alone or In Combination with EtOH: A Sub-Acute Study AU - Mohammed Abdulabbas Hasan AU - Ibtihaj Ahmed kadhim PY - 2022 VL - 2 IS - 33 SP - 117 EP - 135 JO - Journal Of AL-Turath University College مجلة كلية التراث الجامعة SN - 20745621 AB - Dihydromethysticin is a natural supplement that has been used for millennia as a mood booster, relaxant, and pain reliever. The goal of this study was to show the sub-acute toxicity effects of various dosages of dihydromethysticin in rats who were given it orally, as well as to understand the mechanisms of toxicity both alone and in conjunction with EtOH. Abnormal breathing, ataxia, tiredness, lack of appetite, dyspepsia, and loss of coordination were the most prevalent adverse effects, notably in the 800 mg/kg dihydromethysticin therapy group alone, and more severe in the EtOH group. There were dose-related declines in body weight, feed, and water consumption in this research. At a dosage of 800 mg/kg alone, gross and histological studies indicated that the liver was aberrant in color, size, consistency, and weight, with an even higher increase when combined with EtOH. In the periacinar zone of all rats dosed 800 mg/kg of dihydromethysticin alone, hepatocellular hypertrophy (HP) and necrosis, KCs hyperplasia with high proliferation of sER, peroxisome, and swollen mitochondria were observed, and extensive changes were observed in the dihydromethysticin plus EtOH group. Hepatocytes in the periportal (Z1) and mid-zonal (Z2) zones were less damaged than those in the periacinar zone. These findings show that EtOH boosted the sedative and hypnotic activities of dihydromethysticin, as well as the negative consequences. In a dose-dependent way, the histopathological findings corroborated the clinical and biochemical findings, as well as the degree of liver injury.

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