TY - JOUR ID - TI - The Impact of Glycemic Control on Procalcitonin Level in Patients with Type II Diabetes AU - Zainab Abdul-Elah Abbas AU - Zainab Abdul-Elah Abbas PY - 2022 VL - 19 IS - 3 SP - 391 EP - 395 JO - Medical Journal of Babylon مجلة بابل الطبية SN - 1812156X 23126760 AB - Background: Diabetes mellitus is a chronic condition characterized by hyperglycemia that can lead to serious complications. It resultsfrom a defect in insulin secretion, insulin resistance, or both. Type 2 diabetes mellitus (T2DM) is the most common type of diabetesand mainly affects adults. It is associated with insulin resistance and low-grade chronic inflammation in the adipose tissue, muscles, andliver. Measurement of hemoglobin A1c (HbA1c) is one of the most widely used tests to monitor diabetes. The aim of this study wasto shed light on the effect of glycemic control of type 2 diabetes on procalcitonin (PT) levels in order to prevent future complications.Materials and Methods: This case-control study included 68 patients with type 2 diabetes mellitus. At Biochemistry Department,College of Medicine, and University of Baghdad and at Al-Sadiq Teaching Hospital in Al-Hilla City, during the period from July 2020to October 2020. Hemoglobin A1C (HbA1c) was estimated by using an affinity chromatography assay. These patients were dividedaccording to HbA1c level into bad control group (HbA1c > = 7%) which included 36 patients, and good control group (HbA1c<7%) which included 32 patients. Another group of 32 nondiabetic apparently healthy subjects (HbA1c <5.7%) served as controlgroup. Patients with type 1 diabetes mellitus (T1DM), gestational diabetes, insulin-treated type 2 diabetes, history of recent infection,diabetic foot, ischemic heart disease, cerebrovascular disease, or recent trauma or surgery were excluded. PCT of each participant wasestimated using an enzyme-linked immunosorbent assay (ELISA). Results: The mean PCT values of bad control group, good controlgroup, and control groups were 871.3776, 834.5005, and 208.5313 pg/mL, respectively. The study showed that there was no significantdifference in mean PCT between good control and bad control groups (P > 0.05). In addition, there was no significant correlationbetween PCT and HbA1c among diabetic patients (r = 0.072, P > 0.05). However, there is a significant differences in mean of PCTvalues between diabetic patients and control group (P < 0.05). Conclusion: There was no effect of glycemic control on PCT level inpatients with T2DM. However, the level of PCT was increased in comparison with non-diabetic healthy subjects.

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