TY - JOUR ID - TI - SERUM COPPER AND ZINC LEVELS AND COPPER/ZINC RATIO IN PATIENTS WITH RHEUMATOID ARTHRITIS مستويات النحاس والزنك ونسبة النحاس/الزنك في مصل مرضى التهاب المفاصل الرثوى AU - Israa S. Mohammed اسراء سالم محمد AU - Alaa K. Mohammed علاء كريم محمد AU - Yahya Y.Z. Farid يحيى يحيى زكي فريد PY - 2005 VL - 4 IS - 1 SP - 49 EP - 56 JO - IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية SN - 16816579 22244719 AB - Background: Trace elements particularly copper and zinc have a great role in a number of biological processes, therefore estimation of these metals in serum of Rheumatoid Arthritis (RA) patients may ameliorate the understanding of trends in the relationship between the serum copper and zinc levels and activity of disease.Objective:To determine the serum copper and zinc levels and its relation with the degree of disease activity and compare with a normal group.Methods:The investigation was carried out on forty-three healthy (25 females, 18 males) and fifty-four(37 females, 17 males) sick adults.The patients were subdivided according to the activity of the disease(Tentative EULAR Criteria) in to two groups. Of them 29 patients (21 female, 8 male) had low disease activity [age range 32-65 years] and twenty-five patients(16 female, 9 male) had high disease activity [age range 22-52 years]. They were compared with 43 healthy control [age range19-64 years].Serum copper and zinc were determined by using the atomic absorption specrtophotometry.Results: Serum copper level and copper/zinc ratio in patients with RA in both groups were significantlyincreased than the control group. In addition the serum zinc level in patients with low activity RA was significantly decreased and more in high activity disease.Conclutions: As a result, the alteration of copper and zinc levels in the sera patients with RA can related to degree of disease activity and enable to shed more light on the role of trace elements in both physiological and pathological states.Key words: Background: Trace elements particularly copper and zinc have a great role in a number of biological processes, therefore estimation of these metals in serum of Rheumatoid Arthritis (RA) patients may ameliorate the understanding of trends in the relationship between the serum copper and zinc levels and activity of disease.Objective:To determine the serum copper and zinc levels and its relation with the degree of disease activity and compare with a normal group.Methods:The investigation was carried out on forty-three healthy (25 females, 18 males) and fifty-four(37 females, 17 males) sick adults.The patients were subdivided according to the activity of the disease(Tentative EULAR Criteria) in to two groups. Of them 29 patients (21 female, 8 male) had low disease activity [age range 32-65 years] and twenty-five patients(16 female, 9 male) had high disease activity [age range 22-52 years]. They were compared with 43 healthy control [age range19-64 years].Serum copper and zinc were determined by using the atomic absorption specrtophotometry.Results: Serum copper level and copper/zinc ratio in patients with RA in both groups were significantlyincreased than the control group. In addition the serum zinc level in patients with low activity RA was significantly decreased and more in high activity disease.Conclutions: As a result, the alteration of copper and zinc levels in the sera patients with RA can related to degree of disease activity and enable to shed more light on the role of trace elements in both physiological and pathological states.Key words: Rheumatoid Arthtitis, copper, zinc, and serum. .

خلفية الدراسة: عياثر العناصر وخصوصا النحاس والزنك لها دور كبير في العديد من الفعاليات البايولوجية لذلك تقدير تلك العناصر في مصل المرضى المصابين بالتهاب المفاصل الرثوي ربما تحسن الفهم و الادراك نحو العلاقة بين مستوى النحاس و الزنك و بين فعالية المرض.هدف الدراسة: تحديد مستوى النحاس و الزنك في مصل المرضى و علاقتة مع درجة فعالية المرض و مقارنة النتائج مع مجموعة الاصحاء.طريقة العمل: تضمنت 97 شخصا مقسمين الى اربعة و خمسون مريضا (37 اناث،17 ذكور) يعانون من مرض التهاب المفاصل الرثوى و مقسمين الى 29 مريضا (21 اناث،8 ذكور) بمدى عمر يتراوح بين (32 –65سنة) و لديهم فعالية قليلة للمرض و 25 مريضا (16 اناث،9 ذكور) بمدى عمر يتراوح بين (22-52 سنة) و لديهم فعالية مرتفعة للمرض و مقارنة النتائج مع 43 شخص سليم بمدى عمر يتراوح بين (19-64 سنة). تم تقدير مستوى النحاس و الزنك فى مصل المرضى بتقنية مطيافية الامتصاص الذري.النتائج: مستوى النحاس في مصل الدم و كذلك نسبة النحاس/الزنك تزداد بصورة ملحوظة فى كلا المجموعتين قيد الدراسة مقارنة بمستواها فى مصل الاصحاء. اضافة الى انخفاض ملحوظ فى مستوى الزنك فى مصل المرضى ذو الفعالية القليلة و بصورة اكبر عند المرضى ذو الفعالية العالية للمرض.الاستنتاج: ان التغير فى مستوى النحاس و الزنك فى مصل المرضى المصابين بالتهاب المفاصل الرثوى له علاقة بفاعلية و درجة المرض مع تسليط الضوء على اهمية دور العناصر فى الحالات المرضية و الفسيولوجية.مفتاح الكلمات: التهاب المفاصل الرثوى، النحاس، الزنك، المصل. ER -