TY - JOUR ID - TI - Relationship between postprandial hyperglycaemia and Progression of Diabetic Nephropathy AU - Hazem K. Abdul-Kareem AU - Ali S.Abdul-Razzaq Al-hilli PY - 2007 VL - 2 IS - 3 SP - 124 EP - 132 JO - Al-Qadisiyah Medical Journal مجلة القادسية الطبية SN - 18170153 23127864 AB - BACKGROUND: With the recent development of new methods to measure postprandial hyperglycemia and new treatments to modulate it, investigators have questioned whether postprandial hyperglycemia causes diabetic complications such as nephropathy.OBJECTIVES: the aim of our study was to assess the influence of postprandial hyperglycaemia on the incidence of nephropathy in patients with type 2 diabetes.) Patients&METHODS:112 patients attending diabetic clinic in Al-diwanyia teaching hospital fulfilled the criteria of the study. The patients investigated for macroalbuminuria. The patient divided into two groups according to the result of 2 successive measurements of post-challenge plasma glucose level (following 75 gm glucose solution )2 weeks apart .RESULTS: Of total 112 patients with mild-moderate type 2 diabetes for last 5-7 years, about84 patients(75%) had postprandial plasma glucose values>200 mg/dl, 69(82.1%) patients of them had macroalbuminuria,whereas macroalbuminuria observed in 6 patients only ( 25 % of total ) in those with postprandial plasma glucose < 200 mg / dl total ). Macroalbuminuria reported in 7 patients (of the total 112) had normal FPG.

استهدفت الدراسة الوقوف على علاقة ارتفاع نسبة السكر في الدم بعد ساعتين من تناول 75 غم كلوكوز مع الاعتلال الكلوي السكري (ارتفاع نسبة الزلال في الادرار من علاماته المبكرة).كشفت الدراسة عن وجود علاقة وثيقة بين الاثنين بغض النظر عن نسبة السكر الصائم مما يثبت انه عامل مستقل ومن الضروري أخذه بنظر الاعتبار عند المعالجة ER -