TY - JOUR ID - TI - Evaluation of Anticancer Activities of Crude Extracts of Apium graveolens L. Seeds in Two Cell Lines, RD and L20B in vitro تقييم التأثيرات المضادة للتسرطن لمستخلصات الخام لبذور نبات الكرفس Apium graveolens L في أثنين من الخطوط الخلوية L20B و RD في الزجاج AU - Rakad M. Kh. AL-Jumaily ركاد محمد خماس الجميلي PY - 2010 VL - 3 IS - 2 SP - 18 EP - 23 JO - Iraqi Journal of Cancer and Medical Genetics المجلة العراقية للسرطان والوراثة الطبية SN - 20786123 23135379 AB - Present study was designed to evaluate anticancer effect of Apium graveolens seed extracts (aqueous, ethanolic andhexane extracts) in vitro on two cell lines (RD and L20B) using different concentrations of A. graveolens seed extracts(6.25, 12.5, 25, 50, 100 and 200 μg/ml) for an incubation period of 48 hours. The results revealed a clear cytotoxicactivity of those extracts on growth of RD cancer cell line, and the effect was concentration-dependent. The resultsalso, suggested that the hexane extract of A. graveolens showed the best cytotoxic activity on RD cell line, especially atthe concentrations 100 and 200 μg/ml. In contrast, there was no significant cytotoxic effect of the extracts on the L20Btransformed cells, with the exception of hexane extract at the concentration 200 μg/ml, in which a significant growthinhibitory effects were observed.

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