TY - JOUR ID - TI - The Role of Anticardiolipin and Anti-B2 Glycoprotein Antibodies in Clinical Complication of Lupus Nephritis AU - Nawar Abass Abud Noor PY - 2008 VL - 7 IS - 1 SP - 22 EP - 25 JO - Iraqi Postgraduate Medical Journal المجلة العراقية للاختصاصات الطبية SN - 83601608 98932708 AB - ABSTRACT:BACKGROUND:Although there was confliction regarding the association of raised anticardiolipin antibodies (ACL)level with renal disease in systemic lupus erythematosus (SLE), the role of B2glycoprotein as acofactor for ACL binding is established.The presence of ACL &anti-B2GPІ may be directlyinvolved in pathogenesis of antiphospholipid antibodies associated symptoms like recurrent fetalloss, thrombocytopenia and thrombosis.AIM OF STUDY:To study the possible association between some auto antibodies with the most common clinicalcomplication of disease.PATIENTS AND METHODS:The study was conducted on 25 patients with lupus nephritis, attended the renal clinic inspecialized surgical hospital/ medical city /Baghdad, 25 lupus patients without nephritis and 25healthy controls. Enzyme linked immunsorbant assay was used for detection for ACL, anti-B2GP.RESULT:Although there was no significant difference in mean concentrations of ACL and anti- B2GPbetween lupus nephritis and without nephritis (P>0.05), lupus nephritis patients were more likelypositive for ACL. Positivity of 100% For ACL & anti- B2GPwere detected in thromboticcomplication, in fetal loss complication patients more likely to be positive for ACL (75%), anti-B2GP (50%), in thrombocytopenia positivity of ACL &anti-B2GP (75%).CONCLUSION:There was no association between anti-B2GP and renal disease and presence of both ACL &anti-B2GP carry higher risk for thrombosis and recurrent fetal loss.

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