TY - JOUR ID - TI - Activities of Some Purine Metabolic Enzymes in Sera and Tissues Homogenates of patients with Different Cervix and Uterine Diseases AU - Shatha A. Al-Shammaree AU - Hathama R. Hasan PY - 2005 VL - 2 IS - 4 SP - 424 EP - 439 JO - Medical Journal of Babylon مجلة بابل الطبية SN - 1812156X 23126760 AB - Sone aspects of purine metabolism including the activities of some enzymes involved iD purinenucleotides metabolisn: Adenosine deaminase (ADA), AMP- deaminase (AMPDA), 5'-Nocleotidase (5'-NT) and xanthiDe oxidase (XO) were srudied in human sera and tissues ofhealthy women (!$ed as nornralcontrol) and palients with different diseases as follow: Chronic cervicities and uterine sdenomyosis (wlichlvere used as pathological conlrols),benign uterine 1 mors, Prcmal;gnancy group (which represerrr parienEwith chronic cewicilies with mild lo moderate hyperplasia), a d ceryix and utefus cancer.Seveml connnon diflerences in the obtained data, which expressed ir felatioD to prolein contenl.were evident anrong the above groups. The rcsults indicalc tlat thefe were a sigDificant decrease irL sera,ADA and AMPDA specific activiiies of patienls with cervix and terus cancer conpafed with thal ofcontrol, pathological conffol (nalnely: chrooic cervicitis and uterine adenornyosis). benign uterine tLmo,,and premalignancy group(P<0.001). while there were significant increases in ADA and AMPDA specjficactivilies oftissue homogenates ofpalients with cewix and uterus cancer when compared wilh thal of thesanc above meniioned groups (P<0.0J).As fhr as 5'-NT specific activilies was concened, significant increases were obseNed in sera andLissues homogenales ofpatients with cervix and uterus cancer as compared to the othef groups (P <0.01).The dehydrogeuase activities of XO in sem and tissues homogeDates of patients wilh cervix anduterus cancef show a significant decfcase (P <0.05) in comparison to thai ofother gfoups, while thcre wereno derectable oxidase activities ofXo in sefa ofcontrol ard patients with uterus caDce

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