TY - JOUR ID - TI - The mean AgNOR values in relation to HER-2/neu overexpression In a series of Iraqi women AU - Dr. Esraa Abdul-Aal PY - 2009 VL - 12 IS - 2 SP - 128 EP - 136 JO - KUFA MEDICAL JOURNAL مجلة الكوفة الطبية SN - 1993517X 27094462 AB - Background: This study aimed to assess the usefulness of argyrophilic nucleolar organizer regions (AgNORs) in distinguishing HER-2/neu positive from HER-2/neu negative malignant breast lesions.Methods: The present investigation was performed over a period starting from September 2007 to August 2008. Formalin fixed, paraffin-embedded blocks from 90 patients with breast cancer were included in this study. A group of 25 patients with benign breast lesions (fibroadenoma) was included as a comparative group. Labeled Streptavidin-Biotin Complex (LSAB) method was employed for immunohistochemical detection of HER-2/neu. Standardized AgNORs analysis was performed on the above mentioned samples .

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