TY - JOUR ID - TI - Evaluation Of The Psychopharmacological Effects Of Loratadine With Concomitant Adminstration Of Erythromycin AU - Athra M. Salman MBCHB, MSC Asst. Lecturer PY - 2010 VL - 13 IS - 1 SP - 164 EP - 167 JO - KUFA MEDICAL JOURNAL مجلة الكوفة الطبية SN - 1993517X 27094462 AB - AbstractIn this study, the effect of a single oral dose (10 mg) of a 2nd generation antihistaminic agent – loratadine - administered alone or with a metabolic inhibitor – erythromycin - on psychomotor performance was investigated on 6 healthy volunteers.Recording of movement reaction time and assessment of subjective feeling of sedation was done before medication and hourly afterward for 3 hours.The results were analyzed statically by using “student’s t test” which showed that loratadine erythromycin combination induced a statically significant impairment of psychomotor performance demonstrated by prolongation of finger tip reaction time.

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