TY - JOUR ID - TI - 10- HUMAN PARVOVIRUS B19 ANTIBODY AMONG ARTHROPATHIC PATIENTS WITH ESPECIAL EMPHASIS ON SICKLE CELL DISEASES IN BASRAH AU - MUBDER A MOHAMMED SAEED AU - HASSAN J HASONY AU - DANIAH M SHAKIR PY - 2008 VL - 14 IS - 2 SP - 53 EP - JO - Basrah Journal of Surgery مجلة البصرة الجراحية SN - 16833589 2409501X AB - A case control study was carried out during the period from October 2006 till September 2007in Basrah Governorate. To estimate the overall prevalence of Human Parvovirus B19 (HPVB19) antibody and its association to Rheumatoid factor seropositivity among sickler and nonsickler arthropathic patients.A total of 182 blood samples were collected. Ninety (90) from arthropathic patients with orwithout sickle cell diseases (SCD), who attended the orthopaedic, rheumatology and internalmedicine consultant clinics in Basrah General Hospital and Hemoglobinopathies Center at theMaternity and Children Hospital. Ninety two (92) from control group, non arthropathic with orwithout SCD.Human parvovirus B19 IgG antibodies were serologically detected by an Enzyme- LinkedImmunosorbent Assay (ELISA). The rheumatoid factor was detected by Latex agglutination test.The overall prevalence of HPV B19 antibody in Basrah among study population was 68.7% .The prevalence of this antibody was 76.9% among arthropathic non sickler and 65.8% in sicklerarthropathic patients. These differences were shown statistically not significant P> 0.05compared to control group where prevalence was 63.2% in non arthropathic sickler and 66.7%among non arthropathic non sickler individuals.Eighty percent of arthropathic patients who had positive rheumatoid factor were also positive forHPV B19 antibody, which indicate a significant association (P<0.05).In the present study the seropositivity of HPV B19 was shown to be increased with age. Inrelation to site of joint affected, the small joints of the hand and foot were the commonest site ofmanifestation 78.1%.HPV B19 antibody was significantly more (79.7%) among persons with history of bloodtransfusion. The types of SCD had no significant effect on the prevalence of HPV B19 antibody(P>0.05). However there was a positive relation between HPV B19 seropositivity and theduration of illness (P<0.0%).In conclusion, HPV B19 is common with high prevalence in our region. There is clearassociation between HPV B19 infection and rheumatoid factor positivity. Individuals with sicklecell diseases regardless the type and those with history of blood transfusion were considered asrisk groups for acquiring HPV B19 infections.

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