@Article{, title={Evaluation of Thyroid function Status in Hemodialysis Patients}, author={Mohammed F Abdul Mehdi Gamber}, journal={Karbala Journal of Medicine مجلة كربلاء الطبية}, volume={2 no.8, 9}, number={5}, pages={716-724}, year={2009}, abstract={background The interactions between kidney and thyroid functions are knownfor years. Thyroid hormones (TH) are necessary for growth and developmentof the kidney and for the maintenance of water and electrolytes homeostasis.On the other hand, kidney is involved in the metabolism and elimination of TH.Chronic renal failure (CRF) affects thyroid function in many ways, including lowcirculating thyroid hormone levels, altered peripheral hormone metabolism,insufficient binding to carrier proteins, possible reduction in tissue hormone contentand altered iodide storage in the thyroid gland. Thus, patients with renal failure mayhave various abnormalities of thyroid function; nevertheless, they are typicallyclinically euthyroid.Objectives: the aim of the present study is to evaluate thyroid function status inpatients with hemodialysis in Karbala province, and to determine the benefit ofthyroid function test as a routine test requested in hemodialysed patients.Methods: Forty-two hemodialysed patients who attend hemodialysis unit inAl_Hussien teaching hospital in Karbala province with mean age of (44.4±15.9),another 32 apparently healthy subjects with mean age (41.4±12.5) took part in thecurrent study as a control group. An early morning fasting sample of venous bloodfrom each, total trioiodothyronine (TT3), total thyroxine (TT4) and thyroidstimulating hormone TSH were estimated by Enzyme Linked ImmuoSorbent Assay(ELISA).Result: The (TT3) level in haemodialysed patients was significantly lower than thelevel TT3 in control group (P< 0.001).T-student test reveals no significant differencein the total thyroxine (TT4) level between haemodialysed patients and control group.Also There was no significant difference in the mean level of TSH betweenhemodialysis and control group. About 41% of haemodialysed patients have TT3level in the lower tertile of the reference range another 26% have TT3 level below thereference value. There was no correlation between TT3 level in hemodialysis groupand duration of hemodialysis (in months).Conclusion: Abnormalities in thyroid function test in hemodialysis patient are morecommon than that in general population, and low T3 syndrome is considered the maindisorder that affect the thyroid function test in hemodialysis patients. So this disordershould be investigated in those patients routinely as, its presence in hemodialysispatients indicates a bad prognosis for them

} }