@Article{, title={EFFECT OF CHITOSAN SHEET ON INFLAMMATION IN RABBITS تاثير رقائق الكيتوسان على العملية الالتهابية في الارانب}, author={A Ala Al-Deen H. J awad*, J asim M. Al-Diab** and Manal علاء الدين حسن جواد جاسم محمد ذياب منال خليل ابراهيم}, journal={Basrah Journal of Veterinary Research مجلة البصرة للابحاث البيطرية}, volume={5}, number={1}, pages={25-36}, year={2006}, abstract={This study was conducted to investigate the effect of chitosan sheets onA inflammation. Accordingly chitosan sheet was isolated and prepared from theexoskeleton of the native shrimps in Basrah Province. The inflammation was induced andevaluated by polyvinyl sponge to determine the events which occur during theinflammatory process during different intervals in the presence or absence of chitosan‘ sheets .For this purpose 24 male rabbits were used and two linear skin incisions (2 cm)were made on the dorsal aspect in both sides of each rabbit. The inflammatory process atl,3,7&l5 day post wounding was evaluated macroscopically in terms of hyperemia,suppuration, dryness, and adhesion of margins and microscopically in terms of infiltrationof inflammatory cells specially neutrophils and macrophages, fibrovascular granulationtissue. _. The ‘results of macroscopic evaluation revealed that '-It first post wounding day thetest wound was significantly (p<0.05) more hyperemic than control wounds followed bya significant decrease in the severity of hyperemia in test wounds at ls‘, 3rd, 7"‘, and 15"‘post wounding days (p<0.05). The test wounds was more dry with less suppuration to_ words the end of the experiment than control wounds (p<0.05). The adhesive contactbetween the margin of the wounds was significantly higher in test wounds than in controlwounds through out the period of experiment (p<0.05).EFFECT OF CHITOSAN SHEET ON INFLAMMATION INRABBITSA Ala Al-Deen H. J awad*, J asim M. Al-Diab** and ManalKh.Ibraheem****Department of physiology,College of Veterinary Medicine, University of Basrah,Basrah,Iraq.**Department of pathology,College of Medicine, University of Basrah,Basrah,Iraq.‘ ' ***College of Pharmacy, University of Basrah,Basrah,lraq. ‘(Received 22 November 2005,Accepted 13 January 2006)Kcywords;glnflammation,Chitosan,hyperemic.. ABSTRACTThis study was conducted to investigate the effect of chitosan sheets onA inflammation. Accordingly chitosan sheet was isolated and prepared from theexoskeleton of the native shrimps in Basrah Province. The inflammation was induced andevaluated by polyvinyl sponge to determine the events which occur during theinflammatory process during different intervals in the presence or absence of chitosan‘ sheets .For this purpose 24 male rabbits were used and two linear skin incisions (2 cm)were made on the dorsal aspect in both sides of each rabbit. The inflammatory process atl,3,7&l5 day post wounding was evaluated macroscopically in terms of hyperemia,suppuration, dryness, and adhesion of margins and microscopically in terms of infiltrationof inflammatory cells specially neutrophils and macrophages, fibrovascular granulationtissue. _. The ‘results of macroscopic evaluation revealed that '-It first post wounding day thetest wound was significantly (p<0.05) more hyperemic than control wounds followed bya significant decrease in the severity of hyperemia in test wounds at ls‘, 3rd, 7"‘, and 15"‘post wounding days (p<0.05). The test wounds was more dry with less suppuration to_ words the end of the experiment than control wounds (p<0.05). The adhesive contactbetween the margin of the wounds was significantly higher in test wounds than in controlwounds through out the period of experiment (p<0.05).

} }