TY - JOUR ID - TI - Histopathological evaluation of bone healing using Nanobone in experimentally induced frontal bone defects of rabbits AU - Alaa S. Jaber علاء جبار AU - Kadhim A. Al-Soudani كاظم السوداني PY - 2012 VL - 24 IS - 4 SP - 40 EP - 45 JO - Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد SN - 18171869 23115270 AB - Background: The bone substitute biomaterials are used in reconstruction of bone defects and one of them isNanobone. It consists of nanocrystalline hydroxyapatite embedded in a highly porous matrix of silica gel. It promotesthe healing of bone defects and increases the amount of new bone formed. It is degraded and resorbed byosteoclasts after a period of time. The aim of study was to evaluate the effects of Nanobone on bone healing inexperimentally frontal bony defects of rabbits.Materials & Methods: Thirty five indigenous rabbits were used in this study. Granules of Nanobone were implanted insurgically induced defects of 5mm size in one side in the frontal bone of rabbits, while the other side defects were leftfree to heal spontaneously as controls. Samples were taken after 2, 6, 9, 12 and 24 weeks and demineralized. Theamount of new bone formed around implanted granules and the inflammation present were analyzed by means oflight microscopy in both Nanobone granules-filled defects and controls.Results: At 2 weeks, there was no new bone formed in both defects with few amount of inflammation whichconsiders normal at this time. At 6, 9 and 12 weeks , the amount of new bone formed in Nanobone filled defects wasmuch more than that formed in controls (statistically significant correlation, P<0.05), no inflammation seen in boths. At24 weeks, the Nanobone granules were degraded and completely replaced by new bone while in controls therewas few spaces not filled with bone (statistically highly significant correlation, P<0.01), no inflammation seen also.Conclusions: Results of present study revealed that Nanobone material promotes healing of bony defects incomparison to controls and is degraded and replaced by new bone after a period of time

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