TY - JOUR ID - TI - Evaluation of serum anti-cyclic citrullinated peptide antibodies level in rheumatoid patients with and without periodontitis AU - Fatin M. Jarallah فاتن جار الله PY - 2012 VL - 24 IS - 4 SP - 83 EP - 87 JO - Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد SN - 18171869 23115270 AB - Background: Rheumatoid arthritis (RA) and periodontitis (PD) are widely prevalent diseases and are characterized bytissue destruction due to chronic inflammation. Recently, there is growing evidence that the two diseases sharemany pathological features. An association between periodontitis and rheumatoid arthritis has been consideredmany years ago. The current study was established to evaluate the serum ACCP levels in rheumatoid arthritis patientswith and without periodontitis, in addition to study the correlation between serum ACCP levels and periodontalparameters.Subjects and methods: A total of 95 subjects were enrolled in this study, age ranged (35 – 55) years divided into 3groups: Group I consist of 45 rheumatoid arthritis patients with periodontitis, while group II consist of 35 rheumatoidarthritis patients without periodontitis and group ÉÉÉ which consist of 15 apparently- healthy controls. . Periodontalparameters used in this study were plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinicalattachment level (CAL) and bleeding on probing (BOP). Blood samples were collected from each subject todetermine serum concentrations of ACCP by means of enzyme-linked immune-sorbent assay (ELISA).Results: present study revealed that serum ACCP levels were significantly higher in rheumatoid patients withperiodontitis (P<0.001) than that in other two groups. Regarding the correlation between serum ACCP levels andperiodontal parameters, the current study showed positive correlation between serum ACCP and each of plaqueindex, gingival index and probing pocket depth.Conclusion: The current results provide strong evidence of association between periodontitis and rheumatoid arthritis,and suggested that periodontitis may play an important role in activation and triggering immune response

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