TY - JOUR ID - TI - Immunohistochemical expression of Cyclooxygenase 2 and Caspase 7 in oral lichen planus AU - Muna S. Merza منى ميرزا PY - 2012 VL - 24 IS - special issue 2 SP - 61 EP - 64 JO - Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد SN - 18171869 23115270 AB - Background: Oral lichen planus (OLP) is one of the most common dermatological diseases presenting in the oralcavity. Although relatively frequent, OLP is the target of much controversy, especially in relation to its potential formalignancy. This study was conducted to find biological changes in the expression of caspase 7 andcyclooxygenase 2(cox2) in OLP by immuohistochemistry and to explore the correlation between them.Materials and Methods: Fifteen cases of randomly chosen paraffin embedded tissue blocks of OLP with 5 normal oralmucosa cases were included in this study. Immunohistochemistry was performed to evaluate Cox2 and caspase 7proteins expression.Results: The expression of cox2 was positive in all studied cases of OLP with negative expression in normal oralmucosa. Caspase 7 expression was positive in (73%) of the cases of which (36.5%) showed strong positive expressionscore. Non-significant positive correlation was found between the two markers.Conclusion: This study provided further evidence that epithelial cells in OLP undergo apoptotic death, on the otherhand they develop high rate of inflammation which may create a good environment for malignant transformation

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