TY - JOUR ID - TI - Primary Biliary Cirrhosis in a Sample of Iraqi Patient AU - Nawal M. Al-Khalidi, AU - Hadi A.Sayah AU - Hamid Jaber AU - Sadiq Jarallah AU - Jassim M. Al-Maliki PY - 2007 VL - 1 no.2 IS - 1 SP - 110 EP - 115 JO - Karbala Journal of Medicine مجلة كربلاء الطبية SN - 19905483 29580889 AB - Background: Primary biliary cirrhosis(PBC) is an autoimmune liver disease that generally affectsmiddle aged women and it is the most common chronic cholestatic liver disease in adult .There are afew studies described this disease in Iraq .Aim of the study: The aim of this study is to evaluate a sample of Iraqi patients with primary biliarycirrhosis regarding the clinical presentation, investigations and associated diseases.Setting: Gastroenterology and Hepatology teaching hospital-Baghdad-IraqResult: Thirty-two patients involved in this study (mean age 45.9 year), most of patients were female.All patients presented with itching, and most of them with jaundice, about two thirds of patientscomplained of fatiguability and more than half of them had abdominal pain. Eighty–seven percent ofpatients were younger than 60 years old. Fifty percent of them had serum bilirubin less than 6 mg/dl,39.3% had serum bilirubin more than 6 mg/dl .One-third of them had prolong prothrombin time, whileserum alkaline phosphates is elevated in all patients, and about 80% of patients had elevated liverenzymes .About 75% of patients had positive AMA,while ANA was positive in 21.9% of patients.Liver biopsy was compatible with PBC in 56.3% of patients . Primary biliary cirrhosis associated withmany diseases .In this study 28.1% of patients had PBC associated with arthralgia, Sicca syndromefound in 12.5% of patients, 6.3% had full-blown picture of scleroderma, thyroid disease mentioned in6.3 % of patients .Gall bladder stones reported in 9.4 % of patients.

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