@Article{, title={Construction of New Ethambutol Selective Electrodes for Determination Ethambutol in Pharmaceutical Drugs}, author={Nabil S. Nassory}, journal={Al-Mustansiriyah Journal of Science مجلة علوم المستنصرية}, volume={21}, number={6}, pages={170-178}, year={2010}, abstract={Ethambutol selective electrodes were constructed based on ethambutol-phosphotungstate (EMB-PT) complex with different plasticizers; di-butyl phosphate (DBP), tri-butyl phosphate (TBP), di-butyl phthalate (DBPH), o-nitro phenyl octyl ether (NPOE) and di-octyl phthalate (DOPH). The electrodes based on DBP, TBP and DOPH plasticizers gave slopes near to Narnistain slope which are 27.5, 25.2 and 34.5 mV/decade with detection limit of 1.9x10-5 M and concentration range 10-1 to 10-4 M and pH range 3.0 – 8.0. The electrodes based on DBPH and NPOE showed non-Nernistain slopes, 21.5mV/decade for both plasticizers. Interfering of some cations was investigated and shows no interfering with electrodes response. Potentiometric methods were used for measuring ethambutol in pharmaceutical drugs (tablets) and the electrode based on DOPH was used for determination. The recovery obtained from measuring was in good agreements with that given in British Pharmacopeias.

في هذه الدراسة حضرت اقطاب انتفائية لمادة الايثمبوتول الدوائية معتمدة على معقد الدواء مع dodeca-Tungstophoric acid مع مجموعة من المواد الملدن di-butyl phosphate (DBP), Tri-butyl phosphate (TBP), di-butyl phthalate (DBPH),(NPOE) o -phenyl octyl ether وdi octyl phthalate (DOPH) - .اظهرت الاقطاب مع الملدنات DBP, TBP, DOPH انحدر27.5,21.5,34.5 mV/decade على التوالي وبحد تحسسس 1.9x10-5 مولاري وبمدى تركيز خطي 10-1-10-4 مولاري ومدى دالة حامضية 3-8.اما الاقطاب للملدنات DBPH, NPOE اظهرت استجابة غير نرنستية بانحدار 21.5 mV/decade .اظهرت الدراسة عدم وجود تداخل لعدد من الايونات الموجبة الاحادية والثنائية والثلاثية .تم تطبيق هذا القطب على المستضرات الصيدلانية باستحدام قطب المستندعلى DOPH كملدن وقد اعطت نتائج جيدة} }