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this research was aimed to asses the effect of omega-3 against lambda cyhalothrin (LCT) on some biochemical parameters of rats. The experiment was done on 18 male albino rats in Kerbala University /animal house of Pharmacy College for two months ,and the research was done with the agreement of the animal ethical committe in the college. The rats were divided into three groups, control group represented healthy animals, Lambda cyhalothrin group was drenched orally with 10mg/kg/day of this pesticide and the last one was drenched orally with 20mg/kg/ day of omega-3+ 10 mg/Kg/day of LCT. The samples of blood were collected for laboratory analysis and the liver and kidney tissues were excised for histopathological examination.The results showed a significant elevation in (AST , ALT ,Bilirubin and ALP)levels ,as well as parameters such as (urea, and creatinen) in both second and third group in comparing with healthy group. histopathological examination of liver and kidney in animals drenched with LCT showed significant hepatocyte necrosis while in rats intoxicated with( LCT+omega-3) showed significant healing. so this research showed the protective effect of omega-3 in reducing the toxic effects of cyhalothrin pesticide.

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Hepatotoxicity is an acute adverse effect of paracetamol overdose which could be fatal, so in this research we studied the effect of paracetamol on liver enzymes (GPT, GOT, total protein , glucose ,uric acid ) of female rats that drenched green tea. twenty laboratory female rats housed in plastic cages in animal house at Karbala university/ college of pharmacy , the animals divided randomly into five groups ,(G1 control, G2 drenched with 300 mg/kg green tea and 500 mg/kg paracetamol, G3 drenched with 500 mg/kg green tea and 500 mg/kg paracetamol , G4 drenched with 500 mg/kg paracetamol ,G5 drenched with 500 mg/kg green tea ) , the present study found the ability of green tea to protect liver enzyme against the poisonous effect of paracetamol by reducing the higher value of GPT,GOT, Glucose, and evaluated the lower value of Uric acid and total protein causing by paracetamol.

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Hepatotoxicity is an acute adverse effect of paracetamol overdose which could be fatal, so inthis research we studied the effect of paracetamol on liver enzymes (GPT, GOT, total protein,glucose, bilirubin) of female rats that drenched Artichoke. twenty laboratory female rats housed inplastic cages in animal house at university Karbala of / college of pharmacy , the animals dividedrandomly into four groups ,(G1 control, G2 drenched with 500 mg/kg Artichoke and 500 mg/kgparacetamol, G3 drenched with 500 mg/kg paracetamol ,G4 drenched with 500 mg/kg Artichoke ) ,the present study found the ability of Artichoke to protect liver enzyme against the poisonous effectof paracetamol by reducing the higher value of GPT,GOT, glucose, and evaluated the lower valueof bilirubin and total protein causing by paracetamol. Histopathological changes in liver weregreatly reduced on animals treated with artichoke and paracetamol when compared with theparacetamol group .However, animals treated with paracetamol showed severe congestion in centralvein and there is inflammatory cell and degeneration in hepatocyte enlargement in sensoides andnecrosis and odema.

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Sodium valproate (first generation) and oxcarbazepine (second generation) are common antiepileptic drugs used today. The study was conducted to evaluate and compare the toxicity of these two drugs on both renal and hepatic functions test. The experiment was done on 18 female albino rats in Kerbala University /animal house of Pharmacy College and lasted for about two months,and the research was done with the agreement of the animal rights in the college. The rats were divided into three groups, the first group represented healthy animals, second group was drenched orally with 500mg/kg/day of sodium valproate and the third one was drenched orally with100mg/kg/ day of oxcarbazepine. Blood was collected for lab analysis and the hepatic /renal tissues were excised for histological examination. The results showed a significant elevation in liver (AST and ALT) ,as well as parameters such as (urea and creatinine) in both second and third group in comparing with healthy group. histological examination of liver and kidney in animals drenched with valproate showed significant hepatocyte and tubular necrosis while in rats intoxicated with oxcarbazepine showed single hepatocyte necrosis and mild tubular necrosis. In this study, sodium valproate was suggested to have more hepatorenal toxicity than oxcarbazepine and this result was confirmed by both blood tests and histopathological examination.

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