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A simple, cheap, fast, accurate, Safety and sensitive spectrophotometric method for the determination of sulfamethaxazole (SFMx), in pure form and pharmaceutical dosage forms. has been described The Method is based on the diazotization of the drug by sodium nitrite in acidic medium at 5Cº followed by coupling with salbutamol sulphate (SBS) drug to form orange color the product was stabilized and measured at 452 nm Beer’s law is obeyed in the concentration range of 2.5-87.5 μg ml-1 with molar absorptivity of 2.5x104 L mole-1 cm-1. All variables including the reagent concentration, reaction time, color stability period, and sulfamethaxazole /salbutamol ratio were studied in order to optimize the reaction conditions. No interferences were observed Results of analysis were validated statistically and by recovery studies. These methods are successfully employed for the determination of sulfamethaxazole in some pharmaceutical preparations.. The developed method is easy to use and accurate for routine studies relative to HPLC and other techniques.

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A simple sperctrophotometric method for the determination of mesalazine in aqueous solution is achieved. The method is based on the reaction of mesalizine, with excess nitrite, in an acidic medium, to produce the corresponding diazonium salt. After the removal of residual nitrite with sulphamic acid, the diazonium salt was coupled with phlorogycinol reagent in basic medium to produce, an intense yellow-orange coloured water-soluble and stable azo dye which exhibits maximum absorption at 430 nm. Beer,s law is obeyed in the concentration range of 5-300 μg of mesalazine in a fina0.34l volume of 25 ml i.e., 0.2-12 ppm with a molar absorptivity of 3.02×104l.mol-1.cm-1,a relative error of –o.56 to 0.19% and a relative standard deviation of± 0.34 to ±0.91 % depending on the concentration level. The proposed method has been applied successfully to determine mesalazine in pharmaceutical preparation as capsules.

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Abstract A simple, rapid, accurate and sensitive spectrophotometric method for the determination of cefixime has been developed. The method is based on the formation of the schiff’s base between the primary amino group present in cefixime and aldehyde group present in the vanillin reagent to produce a yellow colored complex having maximum absorption at 414 nm. Beeˈs law was obeyed over the concentration range of 2-20µg/ml,with molar absorptivity of 8.22x104 l/mol.cm. The present method is considered to be simple because it does not need heating, hydrolysis and solvent extraction steps. The ingredients often formulated with cefixime have been shown not to interfere, and is suitable for the routine determination of cefixime. The proposed method has been successfully applied for the determination of cefixime in pure form and in pharmaceutical preparations(capsules)

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Abstract A new, simple, selective, sensitive and accurate direct spectrophotometric method has been developed for the determination of roxithromycin in pure form , pharmaceutical preparations and environmental water samples. The method was based on the reaction of roxithromycin with concentrated sulfuric acid to form red color product having absorption maxima at 485nm .The molar absorptivity of the proposed method was 1.34×105 l. mol-1. cm -1 and its absorbance was linear with concentration rang 5- 50 µg/ml . The relative standard deviation of the method was less than 2% and accuracy (average recovery ) was 99.98% .The substance commonly found with roxithromycin did not interfere .The advantages of the proposed method include a high sensitivity and considered to be simple because it does not need heating or solvent extraction steps . The proposed method was successfully applied to the determination of roxithromycin in pure form ,pharmaceutical preparations and in environmental water samples.

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A reverse phase high performance liquid chromatographic method (HPLC) has been developed for the determination of chlordiazepoxide in the pharmaceutical formulations . Separation was achieved using supelco C18 column(25cm x 4.6 mm. 5 μm). The mobile phase (ethanol), adjusted pH to 1.0 with 1N sulfuric acid and pumped at a flow rate of 1.0 ml/min . The peaks were detected at 310 nm. Linearity was obtained in the concentration range of 0.01- 0.20 mg/ml .The method was statistically validated and RSD was found to be less than 1.5 % indicating high degree of accuracy and precision of the proposed HPLC method. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method may be used for determining chlordiazepoxide in pure drug samples, and pharmaceutical dosage forms.

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Scientific journal issued by the College of Pharmacy University of KarbalaDate first number was issued in 2010Numbers that are published in the year (2).

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A simple and sensitive spectrophotometric method was developed for the determination of nitrazepam(NZP) in pharmaceutical tablets. The method was based on oxidative coupling organic reaction of reduced NZP withpyrocatechol in the presence of ferric sulfate to form red water soluble product with maximum absorbance at 510 nm.The reaction conditions were studied and optimized. The linear range for the determination of NZP, and the detectionlimit were 1 – 24 ىg mL-1 and 0.698 ىg mL-1, respectively. The proposed method has been appliedsuccessfully for the determination of NZP in pharmaceutical tablets. A statistical comparison of these results withthose obtained by the British pharmacopoeia procedure using the Student t-test and variance ratio F-test shows a goodagreement and indicates no significant difference in accuracy and precision at the 95% confidence.

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AbstractA simple, rapid, accurate and sensitive spectrophotometric method for determination of metformin hydrochloride has been developed. The proposed method is based on the oxidation of 1-naphthol by sodium hypochlorite and coupling with metformin hydrochloride in the presence of sodium hydroxide to form an intense blue soluble product with maximum absorption at 580 nm. Beerˈs law is obeyed over the concentration range of 2-20µg/ml, with molar absorptivity of 3.66x104 l/mol.cm.The present method is considered to be simple because it does not need either heating or hydrolysis or solvent extraction steps. The ingredients often formulated with metformin hydrochloride have been shown not to interfere, and the proposed method is suitable for the routine determination of metformin hydrochloride. The method has been successfully applied for the determination of metformin hydrochloride in pure form, pharmaceutical preparations(Tablets) and environmental water sample .

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Based on the diazotization reaction of 4-aminoacetophenone with sodium nitrite in acid medium to form diazonium salt, which was coupled with Methyldopa to form a violet reddish soluble azo dye with maximum absorbance at 560 nm,a batch procedure had been developed for the estamination of Methyldopa. Under optimum experimental parameters affecting on the development and stability of the colored product, Beer´s law obeyed in the range (0.5-45) μg.ml-1 with a correlation coefficient (0.9979).The proposed method was successfully applied to the determination of Methyldopa in either pure form and in commercial brands of pharmaceuticals, no interference was observed from common excipients in the formulations. The analytical results obtained by applying this method were in good agreement with labeled values.

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A sensitive spectrophotometric method was proposed for the determination of chloramphenicol (CAP) in pharmaceutical preparations. The method was based on oxidative coupling organic reaction of reduced CAP with pyrocatechol in the presence of ferric sulfate to form red water soluble product with maximum absorbance at 500 nm. The reaction conditions were studied and optimized. The linear range for the determination of CAP, and the detection limit were 1 – 22 µg ml-1 and 0.520 µg ml-1, respectively. The proposed method has been applied successfully for the determination of CAP in pharmaceutical preparations. A statistical comparison of these results with those obtained by the British pharmacopoeia procedure using the Student t-test and variance ratio F-test shows a good agreement and indicates no significant difference in accuracy and precision at the 95% confidence

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