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The calcination treatments and a binder of poly acrylic acid PAA (1wt%) effects on kaolinite particles were investigated through dielectric properties at 1MHz ,quantitative analysis of X-ray diffraction and microstructure. The calcinated samples at 850°C/3hr and fired at 1350°C/2hr were revealed decrease in broadening (Full Width at half maximum) FWHM and increase of dielectric constant.

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Abstarct

In this work a novel drug delivery system through modification of poly acrylic acid with Methionine as a spacer between the poly acrylic acid which was converted to its acyl chloride and reacted with Methionine as spacer unit which has been reacted with Ampicillin drug. In vitro drug release study had been conducted successfully in basic medium in pH 7.4 and acidic medium in pH 1.1 at 37℃. Due to many problems associated with drug release and, this modification could decrease the side effect of drug. The prepared prodrug polymer was characterized by spectra method [FTIR and 1H−NMR]. Physical properties and intrinsic viscosity of drug polymer were determined. The good results were obtained in the presence of spacer unit with comparing without spacer unit.

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