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To eliminate the use of solvent during the course of reaction and to decrease the reaction time in addition to enhanced the yield in synthesis of some Mannich bases 5-((5-(Aryloxymethyl)-1,3,4-thiadiazol-2-ylamino)(phenyl)methyl)pyrimidine-2,4,6 (1H,3H,5H)-trione (2a-h),the reaction was carried out under microwave irradiation of equimolecular mixture of 2-amino-5-aryloxymethyl – 1,3,4 –thiadiazoles (1a-h), benzaldehyde and barbituric acid, using magnesium sulfate as absorption support.In conventional method the attempts to react amine(1a)with aldehyde to form Schiff base and the reaction of this base with barbituric acid did not succeed.The structures of these compounds were confirmed by IR Spectrophotometer. All these bases were screened for their antifungal activity against Aspergillus flavus and found to possess weak activity

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The ligand of 2,2`diamino–N–phenyl hydrazo benzene (L) has been prepared from the reaction of ortho amino hydrazo benzene with ortho amino phenyl thiol in mole ratio1:1and characterized by elemental analysis (C, H, N), IR, UV-Vis. The complexes of bivalent (Co, Ni, Cu, Zn, Pd, Cd, Hg and Pb)ions and trivalent (Cr)ion have been prepared and characterized too. The structural diagnosis were established by IR, UV-Visible spectrum, Conductivities, atomic absorption and magnetic susceptibility. The complexes showed octahedral geometry around the metal ion with the (N,N,N) ligand coordinated in tridentate mode except pd complex showed trigonal bibyramidal. , kf, Єmax for the complexes were estimated too.  for Co – complex was calculated. The study of biological activity of the ligand (L) and its complexes showed various activity toward Streptococcus pyogenes, Staphylococcus aureus, E. coli, Pseudomonas aeruginosa and Candida albicans.

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Objectives: To synthesize three series of new coumarin derivatives and to screen their anticoagulant activity in rabbits in order to define in more exact terms the structural features that responsible for the anticoagulant activity of coumarins.Methods: the first series was synthesized by esterification the 7-hydroxycoumarin with benzoic acid, salicylic acid and 5-amino salicylic acid to give derivatives I-III; the second series was synthesized by the formation of amide linkage between 6-aminocoumarin and benzoic acid, salicylic acid and 5-amino salicylic acid to give derivatives IV-VI while the third series was synthesized by esterification the coumarin-6-carboxylic acid with phenol, resorcinol and m-chlorophenol to give derivatives VII-IX. The anticoagulant activity of these derivatives (I-IX) was investigated in rabbits via Quick's one-stage method; the initial effect of each derivative on the prothrombine time for five rabbits before and after oral administration was measured. Results: The chemical structure of these derivatives was characterized by physical and spectroscopic techniques as FTIR, UV and 13C-NMR spectra. Depending on prothrombin time measurements, derivatives II and VIII showed a significant anticoagulant activity through increasing the prothrombine time while the other derivatives showed an insignificant anticoagulant activity.Conclusion: This study proposed that the coumarin derivatives contained an ester linkage at position 6 or 7 separated from a hydroxyl group by short carbon side chain may show anticoagulant activity.

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in the present investigation new eight poly esrers as schiff bases wich containing pendant imine group were synthesized by treatment of poly acryloyl chlodire with ethanol amine group were synthesized by treatment of poly acryloyl chloride with ethanol

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The paper presents an original method to make the geometric synthesis of the rotary cam and translated tappet with roll. Classical method uses to the geometric synthesis and the reduced tappet velocity, and in this mode the geometric classic method become a geometric and kinematic synthesis method. The new geometric synthesis method uses just the geometric parameters (without velocities), but one utilizes and a condition to realize at the tapped the velocities predicted by the tapped movement laws imposed by the cam profile. Then, it makes the dynamic analyze for the imposed cam profile, and one modify the cam profile geometric parameters to determine a good dynamic response (functionality). In this mode it realizes the dynamic synthesis of the cam, and we obtain a normal functionality.

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Eighteen new cyclic imides (maleimides) conncted to benzothiazole moiety through sulfonamide group were synthesized via multistep synthesis.The first step involved preparation of two maleamic acids N-phenylmaleamic acid and N-benzylmaleamic acid via reaction of maleic anhydride with aniline or benzyl amine.Dehydration of the prepared amic acids by treatment with acetic anhydride and anhydrous sodium acetate in the second step afforded N-phenylmaleimide and N- benzyl maleimide which in turn were treated with chlorosulfonic acid in the third step to afford 4-(N-maleimidyl) phenyl sulfonyl chloride and 4-(N-maleimidyl) benzyl sulfonyl chloride respectively.In the Fourth step of this work each one of the two prepared maleimidyl sulfonyl chlorides was introduced in reaction with nine substituted-2-amino benzothiazole compounds producing nine N-(4-(N-substituted benzothiazole -2-yl) sulfonamido phenyl) maleimides and nine N-(4-(N-substituted benzothiazole-2-yl)snlfonamido benzyl) maleimides.More over another new six sulfonamide phenyl and benzyl maleimides substituted with other heterocycles (pyridine and phenazone )were prepared via reaction of 4-(N-maleimidyl) phenyl and benzyl sulfonyl chlorides with heterocyclic amines including (2-amino pyridine,4-amino-pyridine,4-aminophenazone). Microbiological activity of the prepared compounds against two typs of bacteria(staphylococcus aureus and klebsiella pneumonia) and (candida albicans) fungi were evaluated and the results showed that these compounds have good antibacterial and good antifungal activities.

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In this paper a stirred-bed performed of the copper catalyzed synthesis of ethylchlorosilanes from silicon and ethyl chloride was described. A Si-catalyst mixture prepared by reaction of CuCl and Si was employed. The compositions of products were mainly ethyltrichlorosilane, diethyldichlorosilane, and ethyldichlorosilane and mainly depended on the extent of Cu in the mixture and the reaction temperature. A promoting effect on the extent of adsorption was observed on the addition of certain additives. The kinetic data revealed the direct depended of the reaction rate on C2H5Cl pressure.

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Abstract : A series of novel Azachalcone compounds were prepared by the reaction of 3-acetyl pyridine with different aromatic aldehyd . Azachalcone was reacted with thiourea to give good yields of thiazines , all the new compounds were characterized by I.R , U.V and TLC. Also the Biological Activities of these compounds against anti bacteril and anti fungal were evaluated . some of these compounds gave good activity

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Coupling reaction of 2-amino benzoic acid with 8-hydroxy quinoline gave bidentate azo ligand. The prepared ligand has been identified by Microelemental Analysis,1HNMR,FT-IR and UV-Vis spectroscopic techniques. Treatment of the prepared ligand with the following metal ions (ZnII,CdII and HgII) in aqueous ethanol with a 1:2 M:L ratio and at optimum pH, yielded a series of neutral complexes of the general formula [M(L)2]. The prepared complexes have been characterized by using flame atomic absorption, (C.H.N) Analysis, FT-IR and UV-Vis spectroscopic methods as well as conductivity measurements. The nature of the complexes formed were studied following the mole ratio and continuous variation methods, Beer's law obeyed over a concentration range (1× 10-4- 3 × 10-4 M). High molar absorbtivity of the complex solutions have been observed. The stability constant of the complexes has also been studied.

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A series of new derivatives of α-phenylcinnamoyl thiosemicarbazides have been synthesized and converted to 5-substituted- α-phenylstyryl-1,3,4-triazole-2-thiols.These compounds were screened for their antibacterial activity against Staphylococcus aureus ,Escherichia coli and pseudomonas aeruginosa. It was found that α- phenylcinnamoyl thiosemicarbazides were more active than triazoles against Staphylococcus aureus and Escherichia coli.

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