STUDY THE PROTECTIVE ROLE OF QUERCETIN AGAINST O-ANISIDINE TOXICITY ON SOME HEMATOLOGICAL PARAMETERS OF LABORATORY MALE RATS (RATTUS NORVEGICUS).

Abstract

The study was designed to assess the protective role of Quercetin against Oanisidinetoxicity. 24 male rats (Rattus norvegicus) were used and divided into 3 equalgroups of 8 male rats each. The first group was the control group in which the animalswere fed on a standard ration for 15 days, then they were terminated. The secondgroup was fed on a ration contains 1000mg/kg O-anisidine hydrochloride for 15.Thethird group was fed on a ration contains 1000mg/kg O-anisidine hydrochloride +80mg/kg Quercetin dihydrate for 15. The results revealed that the treatment with Oanisidinehydrochloride for 15 days (1rst treated group) caused significant decrease inthe R.B.C. count, Hb concentration, P.C.V. percentage, neutrophil and lymphocytecounts and it caused significant increase in platelets count, total leukocytes,monocytes, eosinophil and basophil counts, as compared with control group. WhenQuercetin dihydrate was offered as a protective agent in the ration of the 2nd treatedgroup, it showed a significant ameliorating effect by increasing the R.B.C. count, Hbconcentration, P.C.V. percentage, neutrophil and lymphocyte counts and it causedsignificant decrease in platelets count, total leukocytes, monocytes, eosinophil andbasophil counts, as compared with the 1rst treated group. For the blood indices(RDW, MCH, MCHC, MCV, and MPV) there were no significant differences amongall the experiment groups except for the mean platelet volume (MPV), where Oanisidinehydrochloride caused significant decrease in the MPV of the 1rst treatedgroup as compared with control and 2nd treated group at (P≤0.05).