Effect of toprimate on blood glucose level and lipid profile in normal and diabetic rabbits

Abstract

This study was performed on 72 normal and diabetic rabbits allocated to groups to evaluate the effect of anti-epileptic drug topiramate . Both Hyperglycemia and dyslipidemia, are concern with the disorders of chronic metabolic syndromes related to dysfunctional endocrine system , clinically referred to as diabetes mellitus (DM) . DM is defined and categorized on the basis of intrinsic and extrinsic causative factors. Physicians have used the antiepileptic topiramate to treat neuropathic pain in diabetic patient & bipolar disorder , This study was performed to evaluate the effects of anti-epileptic drugs (topiramate) when used in a dose dependent manner on induction of Cytchrom-P450 enzyme with diabetic disease on lipid profile in normal and diabetic rabbits . the obtained results in this study showed that topiramate in a dose of 50 mg/kg has no significant effect on blood cholesterol , LDL and HDL levels with the exception of triglyceride that show a significant changes in compare to both negative and positive control group and also in the same animal group between day 5 to day 20.