Protein C Deficiency in Patients with Retinal Vein Thrombosis


introduction: Retinal vein occlusions are the most common retinal vascular disorder after diabetic retinopathy with several ocular and systemic disorders associated with retinal veins thrombosis. Protein C deficiency as part of inherited thrombophilia due to deficiency of natural anticoagulant may associated with retinal vein thrombosis.The aims of this study were to measure the Protein C concentrations in patients with retinal vein thrombosis and to evaluate its role in the etiology of those patients.Patients, materials and methods: During a period of 6 months a total number of 42 patients who were diagnosed with retinal vein thrombosis while attending the out patient clinic in Karbala, Iraq. From each patient appropriate amount of venous blood was withdrawn and estimated for plasma protein C level, Complete blood count, blood film, ESR, Kaolin clotting time, anticardiolipin antibodies, antinuclear antibody, TSH, blood urea, serum creatinin, random blood sugar and serum cholesterol. For control group individual only protein C estimation was done.Results: Forty-two patients with retinal vein thrombosis were investigated. There were 22 females and 20 males and a mean age of 48 ± 2 years with no significant statistical differences in mean age and sex between the patients and the control group. Decreased levels of PC were found in six (14%) of the patients, and a statistically significant difference was seen for PC concentration between the patients and the control groups.Conclusions: Deficiency of natural anticoagulant proteins, especially protein C, may play a role in the etiology of retinal vein thrombosis and measurement of these parameters with proper prophylaxis especially in young patients may be useful in prevention of venous thrombosis.