Immunohistochemical Expressions of AKT, ATM and Cyclin E in Oral Squamous Cell Carcinoma

Abstract

Background: Understanding the pathogenesis and molecular basis of Oral Squamous Cell Carcinoma (OSCC) hasincreased rapidly over the past few years that is essential to improve patient's prognosis and treatment modalities.The purpose of this study to evaluate the Immunohistochemical expressions of AKT, ATM, AND Cyclin E in oralsquamous cell carcinomaMaterials and methods: This study was performed on a forty formalin-fixed paraffin-embedded blocks whichhistopathologically diagnosed as Oral Squamous Cell Carcinoma. All cases were collected from theHistopathological Laboratory from patients treated surgically at Maxillofacial surgery Department at RamadiTeaching Hospital, Iraq.Results: The immunohistochemical staining of AKT showed positive expression in 38 (95%), ATM showed positiveexpression in 38(95%) and Cyclin E showed positive expression in 36(90%) of the cases.Conclusion: A statically significant correlation was found regarding the immunohistochemical expression of AKT withtumor grade and stage, Cyclin E with the age group and ATM with the clinical appearance