Evaluation of the Effect of Bone Morphogenetic Protein-2 on Stability of Dental Implant

Abstract

Background: The healing period for bone–implant contact takes 3–6 months or even longer. Application ofEscherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2) to implant surfaces hasbeen of great interest on osseointegration due to its osteoinductive potential. The objective of this study was toevaluate the effect of ErhBMP-2 on implant stability.Materials and methods: A total of 48 dental implants were inserted in 15 patients. Twenty four implants coated with0.5 mg/ml ErhBMP-2 (study group). The other 24 implants were uncoated (control group). Each patient was receivedat least two dental implants at the same session. Both groups were followed with repeated implant stabilitymeasurements by means of resonance frequency analysis at different time intervals (at the time of surgery, then at6th and 12th week postoperatively).Results: there was no obvious statistically significant difference in mean of implant stability quotient ISQ betweenstudy and control groups (P > 0.05) at time of surgery, whereas the mean of ISQ values at 6th and at 12th weekpostoperatively were statistically highly significant in the study group compared to the control group (p < 0.01).Conclusion: The results of this study reveal that coating dental implants with ErhBMP-2 increases stability whencompared with uncoated implants