Synthesis, Characterization and Biological Activity of some new phthalimides and maleimides derivetives containing benzothiazole ring

Abstract

In this work, a series of new3-nitro phthalimides and bromo maleimides derivetivescontaining benzothiazole ring were synthesized, the Synthesis of series of N-(substitutedbenzothiazole-2-yl) 3-nitro phthalimide were performed via three steps, the first one involvedpreparation of a series of substituted 2-aminobenzothiazole via reaction of different primaryaromatic amines with ammonium thiocyanate and bromine in glacial acetic acid, In the second step theprepared amino benzothiozoles were introduced in reaction with 3- nitro phthalic anhydride producinga series of N-(substituted benzothiazole-2-yl) 3- nitro phthalamic acid, while Fusion Method used inpreparation of a series N-(substituted benzothiazol-2-yl) bromo maleimide via Fusion The preparedsubstituted 2-aminobenzothiazole with Bromo Maleic anhydride to producing a series of N-(substituted benzothiazol-2-yl) bromo maleimide ,the synthesized compounds were identifieddepending upon physical and spectral method, Microbiological activities of the preparedcompounds against four types of bacteria and one type of fungi were evaluated and the resultsshowed that the most tested compounds have good antibacterial and anti fungi activity .