Effect of Antibiotics Combination on Multidrug Resistant Proteus mirabilis

Abstract

Atotal of three hundred and twenty one samples were collected from midstream urinetaken from patients suffering from urinary tract infections. 39 isolates of Proteus mirabiliswere isolated and identified depending on their morphological properties( cultural andmicroscopical) and biochemical tests. The study has declared that the ratio of separation thisbacterium from women was (8.41%) and it is higher than the ratio of separation in bothchildren and men which ranged (2.8%) and (0.93%) respectively . The antibiotics sensitivityof the isolates were tested against twenty-four antibiotics, the isolates showed high resistance.The impinem , meropenem, amikacin and ciprofloxacin were found more effective. Thecombination of antibiotics showed active synergism effect against multidrugs resistance ofthe isolates, especially between aminoglycoside (Amikacin and gentamycin) and quinolones(Ciprofloxacin and norfloxacin) and cephalosporins antibiotics(Cefotaxim and sefitrixon) andaminoglycoside antibiotics fromone sideand quinolones from other side.