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Cystatin C As Marker for Detection of Renal Function in Comparison to Blood Urea and Serum Creatinine in Patient with Obstructive Uropathy.

Mufeed J. Ewadh --- Zuhair A. AL-Bayati --- Emad H. AL-Jaff

Medical Journal of Babylon مجلة بابل الطبية
ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 4 Pages: 676 -687
Publisher: Babylon University جامعة بابل

Abstract

Diagnoses obstructive uropathy is usually based on changes in serum Creatinine, which is a poor marker of early renal dysfunction, instead used Cystatin C for this purpose. This study aimed to compare the efficacy of Cystatin C with Creatinine and urea in serum to diagnosis uropathy. The current study was preformed (50) patients (34 males and 16 females). Admitted to Al-Hilla teaching Hospital. Control group include (39) healthy person (21 males and 18 females) to measure kidney biochemical measurement including (Cystatin C, Creatinine and urea in serum). In present study results showed the rate of male more than female with non-significant relation at (P value >0.173) between patients and control groups, Obstructive Uropathy found 52% due to ureteric stone in male and female, 28% due to BPH and the other causes followed in different percentage. According to the kidney biochemical tests, results shows there are non- significant correlation between (cystatin C- Creatinine), and (Cystatin C-Urea). The sensitivity and specificity of Cys C marker were 90% and 97,43% respectively. According to S. Cr the sensitivity and specificity were 28% and 94.87% respectively. We concluded Cystatin C has been a more sensitive marker in detection of renal function in obstructive uropathy than Creatinine and urea in Serum.

Keywords

Obstructive Uropathy --- Cystatin C --- Creatinine and urea.