Levels of Cytokines Profile in Polycystic Ovary Syndrome

Abstract

Background: Polycystic ovary syndrome (PCOS) is one of the commonest endocrine disorder of female at reproductive age and it's prevalencein general population as 20%–33%. Objective: The aim of this study was to measure the level of interleukin (IL) 18, IL 6, and tumor necrosisfactor (TNF) in polycystic ovary women and compare their levels with apparently healthy control group. Materials and Methods: A case‑controlstudy was carried out in Basra. In this study, blood samples from 73 women with PCOS and 73 healthy control women were collected fromoutpatients and private gynecological clinics and primary health care centers from different area of Basra during August 2016–March 2017for estimation of their serum levels of IL6, IL18, and TNF alpha by using enzyme‑linked immunosorbent assay technique. Results: It is foundthat serum levels of IL6, IL18, and TNF alpha were elevated in PCOS women, and we conclude that serum levels of IL6, IL18, and TNFalpha are highly statistically significance in PCOS women than in healthy control group. Conclusion: Levels of IL6, IL18, and TNF alphawere highly statistically significant in PCOS comparing to normal women, and these high levels were related to PCOS independent on thepresence of obesity or hyperandrogenism.