Synthesis and Biological Evaluation of some new 2-Thioxoimidazolidin- 4-one Derivatives (part II)

Abstract

In the present work, a various new derivatives of 2-thioxoimidazolidin-4-one have been synthesized starting from reaction of thiosemicarbazide with two substituted aromatic aldehydes (4-bromobenzaldehyde, 4-chlorobenzaldehyde) to afford shiff,s bases (1a,b) which suffering from intermolecular cyclization when treating with ethylchloroacetate to give compound (2a, b), reaction of compound (2a, b) with4-bromobenzaldehyde produce compounds (3a, b), which is award six member ring product (compound 4a, b) when react with ethylacetoacetate. After a series of reactions with different reagents compound (4a, b) converted to anther compounds by reaction with hydrazine, aldehyde and then with chloroacetylchloride bearing β-Lactam moiety. The structures of the newly synthesized compounds have been confirmed on the basis of FT-IR and some of them by 1H-NMR. All of the prepared compounds were tested for their antibacterial activity against E.coli, P. mirabilis, and Staphylococcus and some of these compounds give good results.