Synthesis, Antibacterial and Antifungal Activities for Novel Derivatives of 2,2'-(((1-benzylbenzoimidazol-2-yl) methyl) azanediyl) bis (ethan-1-ol)

Abstract

The compound 2,2'-(((1H-benzo(d) imidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) wasreacted with benzyl bromide to afford compound (1) which used as row material to prepare aseries of compounds through condensation reaction, the starting compound were reacted withtosyl chloride to protect the OH group to afford compound 2, then reacted benzyl bromide toproduce compound (2), then the compound (2) treated with three compounds (2-mercaptobenzthiazole, 2-mercaptobenimidazol and 2-chloromethyl benzimidazole) to formcompounds 3a, b, 4a,b and 5a,b respectively. In the another step the click reaction ofcompound 2, 2'-(((1H-benzo(d)imidazol-2-yl) methyl) azanediyl)bis(ethan-1-ol) withPropargyl bromide produce compound 6 which reacted with sodium azide or benzyl azide toafford the compounds 7 and 8. The synthesized compounds were characterized and measuredthe physical properties via the FT-IR, HNMR, besides to the CHN analysis. These newlycompounds were screened their antibacterial and antifungal activity. Compounds 1, 2a and 8showed significant antibacterial activity as well these compounds exhibited either low ormoderated antifungal activity.