SERUM GAMMA GLUTAMYL TRANSFERASE LEVELS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME: RELATION TO OXIDATIVE STRESS

Abstract

Background: There is increasing evidence on the association between high serum gamma glutamyl transferase (GGT) levels and oxidative stress in women with polycystic ovary syndrome (PCOS). The aim of this study was to examine serum GGT levels in a sample of women with PCOS and to ascertain the relation to oxidative stress.Methods: A case control study included forty women who were clinically diagnosed with PCOS according to Rotterdam criteria and twenty apparently healthy women served as a control group. Following clinical diagnosis, anthropometric measurement was calculated including height, weight and body mass index (BMI). Serum gamma glutamyl transferase, high sensitive C-reactive protein (hs-CRP) and malonyldialdehyde (MDA) were measured.Results: The women with PCOS exhibited significantly higher serum GGT, hs-CRP and MDA levels than did the healthy women (p=0.04, p=0.05, p=0.05) respectively. The correlation between serum GGT levels and hs-CRP was significant among women with PCOS (p=0.05).Conclusion: Our results suggest that mild elevation of serum GGT may be related to oxidative stress in women with PCOS particularly obese.